ArticleBiology of reproduction2020
Consequences of negative energy balance on follicular development and oocyte quality in primiparous sows†.
Article in Biology of reproduction, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 60 citations in OpenAlex.
- Tryptophan supplementation in low-protein diets of sows during late gestation and lactation: Effects on sow performance and piglet growth.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Feed restriction affects follicular development by regulating cell cycle progression in porcine mural granulosa cells.Journal of animal science and biotechnology · 2026Article
- Comparative effectiveness of propylene glycol-based health programs for controlling ketosis and improving performance in dairy cows.Veterinary world · 2026Article
- Refinement of transvaginal ovum pick-up in sows increases oocyte recovery and supports in vitro embryo production.Acta veterinaria Scandinavica · 2026Article
- From Systemic Stress to Ovarian Failure: Heat Stress-Induced Infertility in Pigs as a Model for Reproductive Dysfunction.Current issues in molecular biology · 2026Review
- Assessment of the relationship between lactation feeding patterns, litter performance, and sow characteristics on sow efficiency metrics.Translational animal science · 2026Article
- Lactational high weight loss impairs follicular development by causing mitochondrial dysfunction of ovarian cells in sows and mitigated by butyrate supplement.Journal of advanced research · 2025Article
- Feeding levels during early gestation in a group-housing system for primiparous sows: impact on piglet birthweight and litter uniformity.Animal bioscience · 2025Article
- Effect of gonadotropin administration on reproductive performance in relation to the age at first conception, time of application, and body condition of weaned sow.Archives animal breeding · 2025Article
- IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Systemic and ovarian impacts of heat stress in the porcine model.Reproduction (Cambridge, England) · 2024Review
- Maternal supplementation with konjac glucomannan and κ-carrageenan promotes sow performance and benefits the gut barrier in offspring.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Supplementing a carbohydrate-rich diet from late lactation to insemination increased glucose and insulin levels in weaned sows, leading to improved subsequent piglet birth weight.The Journal of veterinary medical science · 2024Article
- The Role of FNDC4 in Inflammation and Metabolism for Various Diseases.Aging and disease · 2024Review
- Effect of Andrographis paniculata supplementation during the transition period on colostrum yield, immunoglobulin G, and postpartum complications in multiparous sows during tropical summer.Animal bioscience · 2024Article
- Use of chorionic gonadotropins during lactation to optimize postpartum sow reproductive performance: a review.Animal reproduction · 2024Review
- Porcine Follicular Fluid-Derived Exosome: The Pivotal Material for Porcine Oocyte Maturation in Lipid Antioxidant Activity.International journal of molecular sciences · 2023Article
- Effects of nursing a large litter and ovarian response to gonadotropins at weaning on subsequent fertility in first parity sows.Journal of animal science · 2023Article
- Effect of Sow Body Weight at First Service on Body Status and Performance during First Parity and Lifetime.Animals : an open access journal from MDPI · 2022Article
- Article
- Protein Digestion Kinetics Influence Maternal Protein Loss, Litter Growth, and Nitrogen Utilization in Lactating Sows.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic demands of modern hybrid sows have increased over the years, which increases the chance that sows enter a substantial negative energy balance (NEB) during lactation. This NEB can influence the development of follicles and oocytes that will give rise to the next litter. To study effects of a lactational NEB on follicular development, we used 36 primiparous sows of which 18 were subjected to feed restriction (3.25 kg/day) and 18 were full-fed (6.5 kg/day) during the last 2 weeks of a 24.1 ± 0.3 day lactation. Feed restriction resulted in a 70% larger lactational body weight loss and 76% higher longissimus dorsi depth loss, but similar amounts of backfat loss compared to the full fed sows. These changes were accompanied by lower plasma insulin-like growth factor 1 (IGF1) and higher plasma creatinine levels in the restricted sows from the last week of lactation onward. Ovaries were collected 48 h after weaning. Restricted sows had a lower average size of the 15 largest follicles (-26%) and cumulus-oocyte complexes showed less expansion after 22 h in vitro maturation (-26%). Less zygotes of restricted sows reached the metaphase stage 24 h after in vitro fertilization and showed a higher incidence of polyspermy (+89%). This shows that feed restriction had severe consequences on oocyte developmental competence. Follicular fluid of restricted sows had lower IGF1 (-56%) and steroid levels (e.g., β-estradiol, progestins, and androgens), which indicated that follicles of restricted sows were less competent to produce steroids and growth factors needed for oocytes to obtain full developmental competence.
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