ArticlePLoS computational biology2019
Systematically understanding the immunity leading to CRPC progression.
Article in PLoS computational biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Coupled Cell-Intrinsic and Microenvironmental Heterogeneity Drives Divergent Trajectories in Castration-Resistant Prostate Cancer.bioRxiv : the preprint server for biology · 2026Article
- Wnt5a augments intracellular free cholesterol levels and promotes castration resistance in prostate cancer.Journal of translational medicine · 2025Article
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- Potential of Personalized Dendritic Cell-Based Immunohybridoma Vaccines to Treat Prostate Cancer.Life (Basel, Switzerland) · 2023Review
- Automated CT Pancreas Segmentation for Acute Pancreatitis Patients by combining a Novel Object Detection Approach and U-Net.Biomedical signal processing and control · 2023Article
- DapBCH: a disease association prediction model Based on Cross-species and Heterogeneous graph embedding.Frontiers in genetics · 2023Article
- Editorial: Advanced computational systems biology approaches for accelerating comprehensive research of the human brain.Frontiers in genetics · 2023Article
- Automatic classification of nerve discharge rhythms based on sparse auto-encoder and time series feature.BMC bioinformatics · 2022Article
- The study on the morphological changes of oropharynx in patients with complete unilateral cleft lip and palate after palatopharyngeal closure.Frontiers in neuroscience · 2022Article
- Immune-Associated Gene Signatures Serve as a Promising Biomarker of Immunotherapeutic Prognosis for Renal Clear Cell Carcinoma.Frontiers in immunology · 2022Article
- Identification of signaling pathways associated with achaete-scute homolog 1 in glioblastomas through ChIP-seq data bioinformatics.Frontiers in genetics · 2022Article
- Bioinformatics analysis to screen for genes related to myocardial infarction.Frontiers in genetics · 2022Article
- Targeting Inflammatory Signaling in Prostate Cancer Castration Resistance.Journal of clinical medicine · 2021Review
- Privacy protection of medical data in social network.BMC medical informatics and decision making · 2021Article
- Integrating single cell sequencing with a spatial quantitative systems pharmacology model spQSP for personalized prediction of triple-negative breast cancer immunotherapy response.Immunoinformatics (Amsterdam, Netherlands) · 2021Article
- Reverse engineering gene regulatory network based on complex-valued ordinary differential equation model.BMC bioinformatics · 2021Article
- LTF Regulates the Immune Microenvironment of Prostate Cancer Through JAK/STAT3 Pathway.Frontiers in oncology · 2021Article
- The Optimal Tetralogy of Fallot Repair Using Generative Adversarial Networks.Frontiers in physiology · 2021Article
- Digital Pathology Analysis Quantifies Spatial Heterogeneity of CD3, CD4, CD8, CD20, and FoxP3 Immune Markers in Triple-Negative Breast Cancer.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Prostate cancer (PCa) is the most commonly diagnosed malignancy and the second leading cause of cancer-related death in American men. Androgen deprivation therapy (ADT) has become a standard treatment strategy for advanced PCa. Although a majority of patients initially respond to ADT well, most of them will eventually develop castration-resistant PCa (CRPC). Previous studies suggest that ADT-induced changes in the immune microenvironment (mE) in PCa might be responsible for the failures of various therapies. However, the role of the immune system in CRPC development remains unclear. To systematically understand the immunity leading to CRPC progression and predict the optimal treatment strategy in silico, we developed a 3D Hybrid Multi-scale Model (HMSM), consisting of an ODE system and an agent-based model (ABM), to manipulate the tumor growth in a defined immune system. Based on our analysis, we revealed that the key factors (e.g. WNT5A, TRAIL, CSF1, etc.) mediated the activation of PC-Treg and PC-TAM interaction pathways, which induced the immunosuppression during CRPC progression. Our HMSM model also provided an optimal therapeutic strategy for improving the outcomes of PCa treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.