Evidence map›Paper›PMID 31503518›Full record

ArticleEmerging microbes & infections2019

Mutations in the H7 HA and PB1 genes of avian influenza a viruses increase viral pathogenicity and contact transmission in guinea pigs.

Carola Dreier, Patricia Resa-Infante, Swantje Thiele, Stephanie Stanelle-Bertram, Kerstin Walendy-Gnirß, Thomas Speiseder, Annette Preuss, Zacharias Müller, Hans-Dieter Klenk, Jürgen Stech and 1 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Carola DreierViral Zoonosis -One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology , Hamburg , Germany.
Patricia Resa-InfanteInstitute of Virology, University of Veterinary Medicine , Hannover , Germany.
Swantje ThieleViral Zoonosis -One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology , Hamburg , Germany.
Stephanie Stanelle-BertramViral Zoonosis -One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology , Hamburg , Germany.
Kerstin Walendy-GnirßViral Zoonosis -One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology , Hamburg , Germany.
Thomas SpeisederViral Zoonosis -One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology , Hamburg , Germany.
Annette PreussViral Zoonosis -One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology , Hamburg , Germany.
Zacharias MüllerViral Zoonosis -One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology , Hamburg , Germany.
Hans-Dieter KlenkInstitute for Virology, Philipps University of Marburg , Marburg , Germany.
Jürgen StechInstitute for Molecular Virology and Cell Biology, Friedrich-Loeffler-Institute , Greifswald , Germany.
Gülsah GabrielViral Zoonosis -One Health, Heinrich Pette Institute, Leibniz Institute for Experimental Virology , Hamburg , Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Avian influenza A viruses (AIV) of the H7 subtype continue to evolve posing a pandemic threat. However, molecular markers of H7N7 AIV pathogenicity and transmission in mammals remain poorly understood. In this study, we performed a systematic

Indexed as

Disease Transmission, InfectiousAnimalsDisease Models, AnimalFerretsGuinea PigsHemagglutinin Glycoproteins, Influenza VirusInfluenza A Virus, H7N7 SubtypeMutant ProteinsOrthomyxoviridae InfectionsSerial PassageViral ProteinsVirulence FactorsHemagglutinin Glycoproteins, Influenza Virusinfluenza virus polymerase basic protein 1Mutant ProteinsViral ProteinsVirulence Factorsguinea pigsH7 avian influenza A virusesHA and PB1 gene mutationspathogenicitytransmission

Identifiers

PMID31503518
PMCPMC6746284

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.