Evidence map›Paper›PMID 31502824›Full record

ArticleACS nano2019

Counterion-Dependent Mechanisms of DNA Origami Nanostructure Stabilization Revealed by Atomistic Molecular Simulation.

Job A L Roodhuizen, Philip J T M Hendrikx, Peter A J Hilbers, Tom F A de Greef, Albert J Markvoort

Abstract read
In one paragraph

Article in ACS nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Ion NMR for Biomolecular Systems.Journal of molecular biology · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Self-Assembly of DNA Nanostructures in Different Cations.Small (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  12. Article
  13. Self-assembly of DNA nanostructures in different cations.bioRxiv : the preprint server for biology · 2023
    Article
  14. Nucleic acid nanostructures forApplied physics reviews · 2023
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Salting-Out of DNA Origami Nanostructures by Ammonium Sulfate.International journal of molecular sciences · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Job A L Roodhuizen
Philip J T M Hendrikx
Peter A J Hilbers
Tom F A de GreefInstitute for Molecules and Materials , Radboud University , Heyendaalseweg 135 , 6525 AJ Nijmegen , The Netherlands.ORCID 0000-0002-9338-284X
Albert J MarkvoortORCID 0000-0001-6025-9557

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The DNA origami technique has proven to have tremendous potential for therapeutic and diagnostic applications like drug delivery, but the relatively low concentrations of cations in physiological fluids cause destabilization and degradation of DNA origami constructs preventing

Indexed as

Molecular Dynamics SimulationNucleic Acid ConformationDNAIonsNanostructuresPolyaminesDNAIonsPolyaminescationsDNA nanotechnologyDNA origamimolecular dynamicsstabilitystructural integrity

Identifiers

PMID31502824
PMCPMC6764110

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.