SynthesisThe British journal of surgery2019
Systematic review of functional outcome and quality of life after total pancreatectomy.
Synthesis in The British journal of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 5 of them syntheses that pooled it.
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Who cites it
61 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence-based recommendations.United European gastroenterology journal · 2025Guideline
- Completion pancreatectomy or a pancreas-preserving procedure during relaparotomy for pancreatic fistula after pancreatoduodenectomy: a multicentre cohort study and meta-analysis.The British journal of surgery · 2021Pooled it
- Exocrine Pancreatic Insufficiency After Pancreatectomy for Malignancy: Systematic Review and Optimal Management Recommendations.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Pooled it
- Perioperative Nutritional Aspects in Total Pancreatectomy: A Comprehensive Review of the Literature.Nutrients · 2021Pooled it
- Prophylactic total pancreatectomy in individuals at high risk of pancreatic ductal adenocarcinoma (PROPAN): systematic review and shared decision-making programme using decision tables.United European gastroenterology journal · 2020Pooled it
- Quality of life after open versus laparoscopic distal pancreatectomy: long-term results from a randomized clinical trial.BJS open · 2023Trial
- Gastrointestinal symptoms and health-related quality of life before and after pancreatectomy for pancreatic cancer (GO-PANC): longitudinal nationwide study.The British journal of surgery · 2026Article
- Effect of reduction in skeletal muscle quantity and sex differences on postoperative hepatic steatosis following total pancreatectomy.Surgery today · 2026Article
- Total pancreatectomy friend or foe?Hepatobiliary surgery and nutrition · 2026Article
- Actual 10-year survival after total pancreatectomy: a multicenter study.Langenbeck's archives of surgery · 2026Observational
- Article
- Malnutrition and diabetes outcomes 12 months after total pancreatectomy: A descriptive cohort study.JPEN. Journal of parenteral and enteral nutrition · 2026Article
- Comprehensive comparisons of total pancreatectomy versus pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: a double-center, retrospective study.Gland surgery · 2026Article
- How new diabetes technology will improve outcomes after total pancreatectomy?Gland surgery · 2026Article
- Patient-reported outcomes in adults with type 3c diabetes: a scoping review across aetiologies and pancreatic resection extent.Frontiers in endocrinology · 2026Article
- Impact of Preoperative Diabetes on Insulin Management and Nutritional Status After Total or Completion Pancreatectomy.Annals of surgical oncology · 2025Article
- ASO Author Reflections: Diabetic and Nutritional Management After Total or Completion Pancreatectomy: Current Status and Future Perspectives.Annals of surgical oncology · 2025Article
- Invited Editorial: Clinical Relevance of High-Grade Pancreatic Intraepithelial Neoplasia at the Pancreatic Transection Margin in Patients with Pancreatic Ductal Adenocarcinoma.Annals of surgical oncology · 2025Article
- Anaesthesia for pancreatic resection surgery: part 2.BJA education · 2025Review
- Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgeons have traditionally been reluctant to perform total pancreatectomy because of concerns for brittle diabetes and poor quality of life (QoL). Several recent studies have suggested that outcomes following total pancreatectomy have improved, but a systematic review is lacking.
methodsA systematic review was undertaken of studies reporting on outcomes after total pancreatectomy for all indications, except chronic pancreatitis. PubMed, EMBASE (Ovid), and Cochrane Library were searched (2005-2018). Endpoints included functional outcome and QoL.
resultsA total of 21 studies, including 1536 patients, fulfilled the eligibility criteria. During a median follow-up of 20·8 (range 1·5-96·0) months, 18·6 per cent (45 of 242 patients) were readmitted for endocrine-related morbidity, with associated mortality in 1·6 per cent (6 of 365 patients). No diabetes-related mortality was reported in studies including only patients treated after 2005. Symptoms related to exocrine insufficiency were reported by 43·5 per cent (143 of 329 patients) during a median follow-up of 15·9 (1·5-96·0) months. Overall QoL, reported by 102 patients with a median follow-up of 28·6 (6·0-66·0) months, using the EORTC QLQ-C30 questionnaire, showed a moderately reduced summary score of 76 per cent, compared with a general population score of 86 per cent (P = 0·004).
conclusionOverall QoL after total pancreatectomy is affected adversely, in particular by the considerable impact of diarrhoea that requires better treatment. There is also room for improvement in the management of diabetes after total pancreatectomy, particularly with regards to prevention of diabetes-related morbidity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.