Evidence map›Paper›PMID 31502656›Full record

ArticleHistology and histopathology2020

Alendronate effect in esophagus, stomach and liver: an animal based pathological study.

Theodora Papamitsou, Sotiris Sotiriou, Apostolos Papakoulas, Alexandros Toskas, Dimitrios Kamperis, Sofia Karachrysafi, Eva-Maria Dietrich, Stergios Lialiaris, Antonia Sioga

Abstract read
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In one paragraph

Article in Histology and histopathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. From pill to pain: Alendronate-induced esophageal injury-A case report and review.JGH open : an open access journal of gastroenterology and hepatology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Theodora PapamitsouLaboratory of Histology-Embryology, Aristotle University of Thessaloniki (AUTH), Thessaloniki, Greece. paptheo@med.auth.gr.
Sotiris SotiriouLaboratory of Histology-Embryology, Aristotle University of Thessaloniki (AUTH), Thessaloniki, Greece.
Apostolos PapakoulasLaboratory of Histology-Embryology, Aristotle University of Thessaloniki (AUTH), Thessaloniki, Greece.
Alexandros ToskasLaboratory of Histology-Embryology, Aristotle University of Thessaloniki (AUTH), Thessaloniki, Greece.
Dimitrios KamperisLaboratory of Histology-Embryology, Aristotle University of Thessaloniki (AUTH), Thessaloniki, Greece.
Sofia KarachrysafiLaboratory of Histology-Embryology, Aristotle University of Thessaloniki (AUTH), Thessaloniki, Greece.
Eva-Maria DietrichLaboratory of Histology-Embryology, Aristotle University of Thessaloniki (AUTH), Thessaloniki, Greece.
Stergios LialiarisDemocritus University of Thrace (DUTH), Thrace, Greece.
Antonia SiogaLaboratory of Histology-Embryology, Aristotle University of Thessaloniki (AUTH), Thessaloniki, Greece.
Aristotle University of Thessaloniki · GRDemocritus University of Thrace · GR

Funding

- -
6 · The paper itself

Abstract

Bisphosphonates are commonly used in clinical practice. Their effectiveness is indisputable, however their adverse effects, especially in the GI tract, are still controversial. In our report, we demonstrate pathological findings of the effect of systematic alendronate administration in esophagus, stomach and the liver of an in-vivo animal model of 15 Wistar rats. Light microscopy with immunohistochemistry and electron microscopy were used. Microscopic findings of inflammation of the stomach and mild hepatic dysfunction were observed. Conclusively, alendronate can potentially affect gastric mucosa and liver function on this animal experimental model.

Indexed as

AlendronateAnimalsBone Density Conservation AgentsEsophagusFemaleLiverRatsRats, WistarStomachAlendronateBone Density Conservation Agents

Identifiers

PMID31502656
OpenAlexW3021858291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.