Evidence map›Paper›PMID 31502417›Full record

ReviewArthritis care & research2020

Accelerating Medicines Partnership: Organizational Structure and Preliminary Data From the Phase 1 Studies of Lupus Nephritis.

Paul Hoover, Evan Der, Celine C Berthier, Arnon Arazi, James A Lederer, Judith A James, Jill Buyon, Michelle Petri, H Michael Belmont, Peter Izmirly and 5 more

Abstract readReview
In one paragraph

Review in Arthritis care & research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. A population-scale atlas of blood and tissue in lupus nephritis.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Precision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Cellular and molecular interrogation of kidney biopsy specimens.Current opinion in nephrology and hypertension · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Paul HooverBroad Institute of MIT and Harvard, Cambridge, Massachusetts.
Evan DerAlbert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York.
Celine C BerthierUniversity of Michigan, Ann Arbor.
Arnon AraziBroad Institute of MIT and Harvard, Cambridge, Massachusetts.
James A LedererBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Judith A JamesOklahoma Medical Research Foundation, Oklahoma City.
Jill BuyonNew York University School of Medicine, New York, New York.ORCID 0000-0002-3852-7129
Michelle PetriJohns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0003-1441-5373
H Michael BelmontNew York University School of Medicine, New York, New York.
Peter IzmirlyNew York University School of Medicine, New York, New York.
David WofsyUniversity of California, San Francisco.
Nir HacohenBroad Institute of MIT and Harvard, Cambridge, Massachusetts.
Betty DiamondFeinstein Institute for Medical Research, Northwell Health, Manhasset, New York.
Chaim PuttermanAlbert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York.
Anne DavidsonFeinstein Institute for Medical Research, Northwell Health, Manhasset, New York.ORCID 0000-0002-4081-6464

Funding

PEARL: Pathway Exploration and Analysis in Renal LupusUH2AR067688 · NIAMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI DIAMOND, BETTY, WOFSY, DAVID · 2014 to 2020
$9.0M
Tissue Acquisition Research GroupUM2AR067678 · NIAMS · STANFORD UNIVERSITY · PI HOLERS, VERNON MICHAEL, UTZ, PAUL JOSEPH · 2014 to 2020
$8.2M
Multi-Ethnic Translational Research Optimization (METRO) Lupus ConsortiumUH2AR067689 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BUYON, JILL P, PUTTERMAN, CHAIM · 2014 to 2020
$6.3M
Evolving Adaptive and Effector Mechanisms from Pre-RA Through Established DiseaseUH2AR067681 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI HOLERS, VERNON MICHAEL · 2014 to 2020
$5.5M
Molecular and Cellular Dissection of Early Rheumatoid ArthritisUH2AR067694 · NIAMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI BRENNER, MICHAEL B., GREGERSEN, PETER K. · 2014 to 2020
$5.4M
RA-SLE Molecular Deconstruction Leadership CenterUH2AR067677 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B., RAYCHAUDHURI, SOUMYA · 2014 to 2020
$4.3M
Hopkins Lupus CohortR01AR069572 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI PETRI, MICHELLE A · 2016 to 2020
$3.4M
Cellular Dynamics at the Synovium-Bone interface in RAUH2AR067690 · NIAMS · UNIVERSITY OF ROCHESTER · PI ANOLIK, JENNIFER HOWITT · 2014 to 2020
$3.0M
Stanford Technology Accelerating Medicines Partnership CenterUH2AR067676 · NIAMS · STANFORD UNIVERSITY · PI ROBINSON, WILLIAM H, UTZ, PAUL JOSEPH · 2014 to 2020
$2.6M
Accelerating Medicines Partnership in RA and Lupus: Network Sites (UH2/UH3)UH2AR067679 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI PETRI, MICHELLE A · 2014 to 2020
$2.1M
Molecular Pathways in Treatment Response and Flare in RAUH2AR067691 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI BYKERK, VIVIAN P, IVASHKIV, LIONEL B · 2014 to 2020
$2.0M
UPITT Rheumatoid Arthritis Combined Center (UPITT RACC)UH2AR067685 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCGEACHY, MANDY J, MORELAND, LARRY W · 2014 to 2019
$1.2M
AbbVieAccelerating Medicines PartnershipArthritis FoundationBristol-Myers SquibbLupus Foundation of AmericaLupus Research AllianceMerck Sharp & DohmeNational Institute of Allergy and Infectious DiseasesNIAMS NIH HHS R01 AR069572NIAMS NIH HHS UH2 AR067676NIAMS NIH HHS UH2 AR067677NIAMS NIH HHS UH2 AR067679NIAMS NIH HHS UH2 AR067681NIAMS NIH HHS UH2 AR067685NIAMS NIH HHS UH2 AR067688NIAMS NIH HHS UH2 AR067689NIAMS NIH HHS UH2 AR067690NIAMS NIH HHS UH2 AR067691NIAMS NIH HHS UH2 AR067694NIAMS NIH HHS UM2 AR067678NIH HHS AR-069572NIH HHS UH2-AR-067694PfizerRheumatology Research FoundationSanofi
6 · The paper itself

Abstract

The Accelerating Medicines Partnership (AMP) Lupus Network was established as a partnership between the National Institutes of Health, pharmaceutical companies, nonprofit stakeholders, and lupus investigators across multiple academic centers to apply high-throughput technologies to the analysis of renal tissue, urine, and blood from patients with lupus nephritis (LN). The AMP network provides publicly accessible data to the community with the goal of generating new scientific hypotheses and improving diagnostic and therapeutic tools so as to improve disease outcomes. We present here a description of the structure of the AMP Lupus Network and a summary of the preliminary results from the phase 1 studies. The successful completion of phase 1 sets the stage for analysis of a large cohort of LN samples in phase 2 and provides a model for establishing similar discovery cohorts.

Indexed as

Preliminary DataAcademic Medical CentersBiomarkersClinical Trials, Phase I as TopicDrug IndustryHumansLupus NephritisNational Institutes of Health (U.S.)Public-Private Sector PartnershipsSequence Analysis, RNAUnited StatesBiomarkers

Identifiers

PMID31502417
PMCPMC6992476

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.