ArticleJournal of cardiovascular electrophysiology2019
Relationship between time-to-isolation and freeze duration: Computational modeling of dosing for Arctic Front Advance and Arctic Front Advance Pro cryoballoons.
Article in Journal of cardiovascular electrophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Validation of a prediction model for early reconnection after cryoballoon ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Computer Simulation of Catheter Cryoablation for Pulmonary Vein Isolation.Healthcare (Basel, Switzerland) · 2024Article
- Association of left atrial wall thickness with recurrence after cryoballoon ablation of paroxysmal atrial fibrillation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Variation in the frozen lesion size according to the non-occluded application duration and technique for cryoballoon ablation.PloS one · 2024Article
- Cryoballoon ablation of peri-mitral atrial flutter refractory to radiofrequency ablation: a case report.European heart journal. Case reports · 2024Article
- Single-shot technique of cryoablation for atrial fibrillation has comparable effective and safety outcomes compared to standard technique: insights from multiple clinical studies.Frontiers in cardiovascular medicine · 2023Review
- The advantages and disadvantages of the novel fourth-generation cryoballoon as compared to the second-generation cryoballoon in the current short freeze strategy.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2022Article
- Relationship between time-to-isolation and freeze duration: Computational modeling of dosing for Arctic Front Advance and Arctic Front Advance Pro cryoballoons.Journal of cardiovascular electrophysiology · 2019Article
- Stay frosty - Improving outcomes from cryoballoon pulmonary vein isolation.Indian pacing and electrophysiology journalArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundPreclinical and clinical studies have utilized periprocedural parameters to optimize cryoballoon ablation dosing, including acute time-to-isolation (TTI) of the pulmonary vein, balloon rate of freezing, balloon nadir temperature, and balloon-thawing time. This study sought to predict the Arctic Front Advance (AFA) vs Arctic Front Advance Pro (AFA Pro) ablation durations required for transmural pulmonary vein isolation at varied tissue depths.
methodsA cardiac-specific, three-dimensional computational model that incorporates structural characteristics, temperature-dependent cellular responses, and thermal-conductive properties was designed to predict the propagation of cold isotherms through tissue. The model assumed complete cryoballoon-to-pulmonary vein (PV) circumferential contact. Using known temperature thresholds of cardiac cellular electrical dormancy (at 23°C) and cellular nonviability (at -20°C), transmural time-to-isolation electrical dormancy (TTI
resultsFor cardiac thickness of 0.5, 1.25, 2.0, 3.0, 4.0, and 5.0 mm, the 23°C isotherm passed transmurally in 33, 38, 46, 62, 80, and 95 seconds during cryoablation utilizing AFA and 33, 38, 46, 63, 80, and 95 seconds with AFA Pro. Using the same cardiac thicknesses, the -20°C isotherm passed transmurally in 40, 55, 78, 161, 354, and 696 seconds during cryoablation with AFA and 40, 54, 78, 160, 352, and 722 seconds with AFA Pro.
conclusionThis model predicted a minimum duration of cryoballoon ablation (TTI
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