Evidence map›Paper›PMID 31502290›Full record

ReviewJournal of neuroscience research2019

Aberrant features of in vivo striatal dynamics in Parkinson's disease.

Kwang Lee, Sotiris C Masmanidis

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neuroscience research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kwang LeeDepartment of Neurobiology and California Nanosystems Institute, University of California, Los Angeles, California.ORCID 0000-0002-2689-0350
Sotiris C MasmanidisDepartment of Neurobiology and California Nanosystems Institute, University of California, Los Angeles, California.ORCID 0000-0002-8699-3335

Funding

The Role of Striosome Neurons in Mediating Opiod RewardP50DA005010 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, XIANGDONG WILLIAM · 1987 to 2021
$30.7M
Cortical Pathophysiology in Mouse Models of Huntington's DiseaseR01NS096994 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEVINE, MICHAEL S. · 2017 to 2020
$2.0M
Regulation of nucleus accumbens reward processing by diverse input signalsR01DA042739 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MASMANIDIS, SOTIRIS · 2017 to 2021
$1.7M
CRCNS: Network mechanisms of the learning and encoding of timed motor responsesR01NS100050 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUONOMANO, DEAN V, MASMANIDIS, SOTIRIS · 2016 to 2020
$1.5M
Cortical Pathophysiology in Mouse Models of Huntington's DiseaseR56NS096994 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEVINE, MICHAEL S. · 2016 to 2016
$535k
NIDA NIH HHS P50 DA005010NIDA NIH HHS R01 DA042739NINDS NIH HHS R01 NS096994NINDS NIH HHS R01 NS100050NINDS NIH HHS R56 NS096994
6 · The paper itself

Abstract

The striatum plays an important role in learning, selecting, and executing actions. As a major input hub of the basal ganglia, it receives and processes a diverse array of signals related to sensory, motor, and cognitive information. Aberrant neural activity in this area is implicated in a wide variety of neurological and psychiatric disorders. It is therefore important to understand the hallmarks of disrupted striatal signal processing. This review surveys literature examining how in vivo striatal microcircuit dynamics are impacted in animal models of one of the most widely studied movement disorders, Parkinson's disease. The review identifies four major features of aberrant striatal dynamics: altered relative levels of direct and indirect pathway activity, impaired information processing by projection neurons, altered information processing by interneurons, and increased synchrony.

Indexed as

AnimalsBasal GangliaBehavior, AnimalCorpus StriatumDisease Models, AnimalHumansInterneuronsNeural PathwaysNeuronsParkinson Diseasemovement disordersParkinson'ssingle-unit neural activity

Identifiers

PMID31502290
PMCPMC6801089

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.