ReviewAmerican journal of cardiovascular drugs : drugs, devices, and other interventions2020
Postoperative Atrial Fibrillation Following Cardiac Surgery: From Pathogenesis to Potential Therapies.
Review in American journal of cardiovascular drugs : drugs, devices, and other interventions, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07482540 (The Prophylactic Role of Dexmedetomidine Drug in Reducing Early Postoperative New Onset Atrial Fibrillation After Mitral Valve Surgery - a Randomized Controlled Clinical Trial), which is not on this map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Prophylactic Role of Dexmedetomidine Drug in Reducing Early Postoperative New Onset Atrial Fibrillation After Mitral Valve Surgery - a Randomized Controlled Clinical Trial
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Dexmedetomidine vs. propofol on arrhythmia in cardiac surgery: a meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2024Pooled it
- Does Dexmedetomidine Reduce the Risk of Atrial Fibrillation and Stroke After Adult Cardiac Surgery? A Systematic Review and Meta-analysis of Randomized Controlled Trials.Anatolian journal of cardiology · 2022Pooled it
- Influence of Dexmedetomidine on Post-operative Atrial Fibrillation After Cardiac Surgery: A Meta-Analysis of Randomized Controlled Trials.Frontiers in cardiovascular medicine · 2021Pooled it
- Short-Term, Weight-Adjusted Colchicine to Prevent Post-CABG Arrhythmias: A Randomized, Double-Blind, Controlled Trial.Pacing and clinical electrophysiology : PACE · 2026Trial
- Magnesium Sulfate to Prevent Perioperative Atrial Fibrillation in Cardiac Surgery: A Randomized Clinical Trial.Critical care medicine · 2026Trial
- A Prospective Study of Marsh PK-PD Model and Schnider PK-PD Model During Anesthesia Induction for Obese Patients Undergoing Elective Heart Surgery.Pharmacology research & perspectives · 2026Trial
- Predictive factors and pharmacological preventive interventions for atrial fibrillation after aortic valve replacement.Journal of cardiothoracic surgery · 2025Trial
- Landiolol for preventing postoperative atrial fibrillation: lessons from Japan for all?Journal of thoracic disease · 2026Article
- Exploratory Modeling of Postoperative Atrial Fibrillation After Cardiac Surgery with Cardiopulmonary Bypass Using Inflammatory Biomarkers and Clinical-Surgical Factors.Medical sciences (Basel, Switzerland) · 2026Article
- Can Lactate Values Predict Postoperative Atrial Fibrillation Following Coronary Artery Bypass Graft Surgery? A Prospective Observational Study.Brazilian journal of cardiovascular surgery · 2026Observational
- Review
- Association of Prognostic Nutritional Index and New-Onset Atrial Fibrillation in Patients Undergoing Surgical Aortic Valve Replacement: A Silent Predictor in Perioperative Outcomes?Journal of clinical medicine · 2026Article
- Impact of postoperative atrial fibrillation (POAF) on outcomes after coronary artery bypass grafting: A meta-analysis of unique 247,270 patients from 50 studies.American heart journal plus : cardiology research and practice · 2025Review
- Development and validation of a risk prediction model for postoperative pneumonia in elderly non-cardiac surgery patients: a retrospective cohort study.Scientific reports · 2025Article
- Impact of new-onset atrial fibrillation in patients with ST-segment elevation myocardial infarction.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Article
- Relevance of Targeting Oxidative Stress, Inflammatory, and Pro-Resolution Mechanisms in the Prevention and Management of Postoperative Atrial Fibrillation.Antioxidants (Basel, Switzerland) · 2025Review
- The Effect of Silymarin on the Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting.Brazilian journal of cardiovascular surgery · 2024Article
- Article
- Association of CYP2C19 genotypes with postoperative atrial fibrillation after coronary artery bypass surgery.Clinical and translational science · 2024Article
- Effects of Preoperative Nutritional Status and Lymphocyte Count on the Development of Early-term Atrial Fibrillation After Coronary Artery Bypass Grafting: A Retrospective Study.Brazilian journal of cardiovascular surgery · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative atrial fibrillation (POAF) is a major complication after cardiac surgery which can lead to high rates of morbidity and mortality, an enhanced length of hospital stay, and an increased cost of care. POAF is postulated to be a multifactorial phenomenon; however, some major pathogeneses have been proposed, including inflammatory pathways, oxidative stress, and autonomic dysfunction. Genetic studies also showed that inflammatory pathways, beta-1 adrenoreceptor variants, G protein-coupled receptor kinase 5 gene variants, and non-coding single-nucleotide polymorphisms in the 4q25 chromosomal locus are involved in this phenomenon. Moreover, several predisposing factors lead to the development of POAF, consisting of pre-, intra-, and postoperative contributors. The main predisposing factors comprise age, prior history of major cardiovascular risk factors, and ischemia-reperfusion injury during surgery. The management of POAF is based on the usual therapies used for non-surgical AF, including medications for either rate control or rhythm control in hemodynamically unstable patients. The perioperative administration of β-blockers and some antiarrhythmic agents has been recommended in major international guidelines. In addition, upstream therapies consisting of colchicine, magnesium, statins, and antioxidants have attenuated the incidence of POAF; however, some uncomfortable side effects developed in large randomized trials. The use of anticoagulation has also resulted in less mortality in patients with POAF at higher risk of thromboembolic events. Despite these recommendations, the actual regimen for the prevention of POAF remains controversial. In this review, we highlight the pathogenesis, predisposing factors, and potential therapeutic options for the management of patients at risk for or with POAF following cardiac surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.