ArticleOdontology2020
Japanese subgingival microbiota in health vs disease and their roles in predicted functions associated with periodontitis.
Article in Odontology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Periodontal disease and cardiovascular disease: umbrella review.BMC oral health · 2024Pooled it
- Bacteria of healthy periodontal tissues as candidates of probiotics: a systematic review.European journal of medical research · 2024Pooled it
- Changes in oral microflora following 0.3% cetylpyridinium chloride-containing mouth spray intervention in adult volunteers after professional oral care: Randomized clinical study.Clinical and experimental dental research · 2023Trial
- Clinical utility of subgingival plaque-specific bacteria in salivary microbiota for detecting periodontitis.PloS one · 2021Trial
- OAPGC: a high-quality oral and airway prokaryotic genome catalog for enhanced ecological resolution and disease inference.NPJ biofilms and microbiomes · 2026Article
- In-Depth Multi-Approach Analysis of WGS Metagenomics Data Reveals Signatures Potentially Explaining Features in Periodontitis Stage Severity.Dentistry journal · 2025Article
- The impact of vaping behavior on functional changes within the subgingival microbiome.Scientific reports · 2025Article
- Article
- Bacterial translocation signatures and subgingival microbiome in individuals with periodontitis.Clinical oral investigations · 2025Article
- The blood pressure lowering effect of beetroot juice is impaired in periodontitis and recovered after periodontal treatment.NPJ biofilms and microbiomes · 2025Article
- The Human Oral Microbial Consortium Associated With Periodontitis Attenuates Weight Loss in Dextran Sulfate Sodium-Induced Colitis.Gastro hep advances · 2025Review
- In Vitro Acid Resistance of PathogenicGastro hep advances · 2025Article
- Saliva Proteome, Metabolome and Microbiome Signatures for Detection of Alzheimer's Disease.Metabolites · 2024Article
- Commensal Neisseria Inhibit Porphyromonas Gingivalis Invasion of Gingival Epithelial Cells.Oral health & preventive dentistry · 2024Article
- Association Between Oral Microbiota and Gastrointestinal/Extra-Gastrointestinal Diseases.The Korean journal of helicobacter and upper gastrointestinal research · 2024Review
- Association ofDentistry journal · 2024Article
- Nitrate reduction capacity of the oral microbiota is impaired in periodontitis: potential implications for systemic nitric oxide availability.International journal of oral science · 2024Article
- Effect of 15 days -6° head-down bed rest on microbial communities of supragingival plaque in young men.Frontiers in microbiology · 2024Article
- Mediterranean diet: a potential player in the link between oral microbiome and oral diseases.Journal of oral microbiology · 2024Review
- Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation.Immunological reviews · 2023Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The present study aimed to identify and compare the microbial signatures between periodontally healthy and periodontitis subjects using 454 sequences of 16S rRNA genes. Subgingival plaque samples were collected from ten periodontally healthy subjects and ten matched chronic periodontitis patients. Bacterial DNA was extracted and next-generation sequencing of 16S rRNA genes was performed. The microbial composition differed between healthy subjects and periodontitis patients at all phylogenetic levels. Particularly, 16 species, including Lautropia mirabilis and Neisseria subflava predominated in healthy subjects, whereas nine species, including Porphyromonas gingivalis and Filifactor alocis predominated in periodontitis. UniFrac, a principal coordinate and network analysis, confirmed distinct community profiles in healthy subjects and periodontitis patients. Using predicted function profiling, pathways involved in phenylpropanoid, GPI-anchor biosynthesis, and metabolism of alanine, arginine, aspartate, butanoate, cyanoamino acid, fatty acid, glutamate, methane, proline, and vitamin B6 were significantly over-represented in periodontitis patients. These results highlight the oral microbiota alterations in microbial composition in periodontitis and suggest the genes and metabolic pathways associated with health and periodontitis. Our findings help to further elucidate microbial composition and interactions in health and periodontitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.