Evidence map›Paper›PMID 31502073›Full record

ReviewCurrent pain and headache reports2019

Role of Alpha-2-Microglobulin in the Treatment of Osteoarthritic Knee Pain: a Brief Review of the Literature.

Vwaire Orhurhu, Ruben Schwartz, Jacob Potts, Jacqueline Peck, Ivan Urits, Mariam Salisu Orhurhu, Charles Odonkor, Omar Viswanath, Alan Kaye, Jatinder Gill

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Cyclic Mechanism Affects Lumbar Spine Creep Response.Annals of biomedical engineering · 2026
    Article
  2. Influence of medicinal treatment on the course of nonspecific acute low back pain in older adults: generalized estimating equation using data from the BACE Study - Brazil.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Observational
  3. Regenerative Medicine: The Next Generation of Autologous Blood Formulations.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Vwaire OrhurhuDepartment of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA. Vwo569@mail.harvard.edu.
Ruben SchwartzDepartment of Anesthesiology, Mount Sinai Medical Center of Florida, Miami, FL, USA.
Jacob PottsDepartment of Bioengineering, Northeastern University, Boston, MA, USA.
Jacqueline PeckDepartment of Anesthesiology, Mount Sinai Medical Center of Florida, Miami, FL, USA.
Ivan UritsDepartment of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.
Mariam Salisu OrhurhuDepartments of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Charles OdonkorDepartment of Anesthesia, Critical Care and Pain Medicine, Division of Pain, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Omar ViswanathValley Anesthesiology and Pain Consultants, Phoenix, AZ, USA.
Alan KayeDepartment of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Jatinder GillDepartment of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.
Beth Israel Deaconess Medical Center · USMount Sinai Medical Center · USArizona Pain Specialists · USJohns Hopkins University · USLouisiana State University Health Sciences Center New Orleans · USMassachusetts General Hospital · USNortheastern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewChronic knee pain remains a debilitating condition that remains difficult to manage. The purpose of this review, therefore, is to summarize current understanding of alpha-2-microglobulin in the treatment of osteoarthritic knee pain. Furthermore, we investigate its role in the anti-inflammatory properties of platelet-rich plasma (PRP). RECENT

findingsAlpha-2-microglobulin, a 720-kD protein complex, is an active protease inhibitor with tremendous anti-inflammatory properties in animal models. A growing body of evidence suggests that this complex is the most instrumental factor for cartilage preservation in PRP injections. As an active component of platelet-rich plasma's anti-inflammatory properties, alpha-2-microglobulin has been shown to be an active inhibitor of joint degeneration, cartilage preservation, and improvement in quality of life for patients with knee osteoarthritis compared with a multitude of other modalities.

Indexed as

Alpha-GlobulinsHumansInjections, Intra-ArticularOsteoarthritis, KneePlatelet-Rich Plasmaalpha(2)-microglobulinAlpha-GlobulinsAlpha-2-microglobulinOsteoarthritisPlatelet-rich plasmaProteinase

Identifiers

PMID31502073
OpenAlexW2972680338

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.