Evidence map›Paper›PMID 31502058›Full record

ArticleEuropean journal of nutrition2020

Creatinine, total cysteine and uric acid are associated with serum retinol in patients with cardiovascular disease.

Thomas Olsen, Kathrine J Vinknes, Rune Blomhoff, Vegard Lysne, Øivind Midttun, Indu Dhar, Per M Ueland, Gard F T Svingen, Eva K R Pedersen, Christian A Drevon and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Thomas OlsenDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Domus Medica, Sognsvannsveien 9, 0372, Oslo, Norway. thomas.olsen@medisin.uio.no.ORCID http://orcid.org/0000-0003-1805-5221
Kathrine J VinknesDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Domus Medica, Sognsvannsveien 9, 0372, Oslo, Norway.ORCID http://orcid.org/0000-0002-0756-5042
Rune BlomhoffDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Domus Medica, Sognsvannsveien 9, 0372, Oslo, Norway.ORCID http://orcid.org/0000-0001-7329-3615
Vegard LysneCentre for Nutrition, Department of Clinical Science, University of Bergen, Haukelandsbakken, 5009, Bergen, Norway.ORCID http://orcid.org/0000-0002-0816-5075
Øivind MidttunBevital AS, Jonas Lies vei 87, 5021, Bergen, Norway.ORCID http://orcid.org/0000-0003-2937-5351
Indu DharCentre for Nutrition, Department of Clinical Science, University of Bergen, Haukelandsbakken, 5009, Bergen, Norway.
Per M UelandCentre for Nutrition, Department of Clinical Science, University of Bergen, Haukelandsbakken, 5009, Bergen, Norway.ORCID http://orcid.org/0000-0002-1903-0571
Gard F T SvingenDepartment of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, 5021, Bergen, Norway.ORCID http://orcid.org/0000-0001-9391-8352
Eva K R PedersenDepartment of Heart Disease, Haukeland University Hospital, Jonas Lies vei 65, 5021, Bergen, Norway.ORCID http://orcid.org/0000-0002-2545-1866
Christian A DrevonDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Domus Medica, Sognsvannsveien 9, 0372, Oslo, Norway.ORCID http://orcid.org/0000-0002-7216-2784
Helga RefsumDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Domus Medica, Sognsvannsveien 9, 0372, Oslo, Norway.ORCID http://orcid.org/0000-0003-0382-5633
Ottar K NygårdCentre for Nutrition, Department of Clinical Science, University of Bergen, Haukelandsbakken, 5009, Bergen, Norway.ORCID http://orcid.org/0000-0002-4885-1010
University of Oslo · NOHaukeland University Hospital · NOBevital (Norway) · NOUniversity of Bergen · NOOslo University Hospital · NO

Funding

EkstraStiftelsen Helse og Rehabilitering N/AHaukeland Universitetssjukehus N/AHelse Vest Regionalt Helseføretak N/ALandsforeningen for Hjerte- og Lungesyke N/ANorges Forskningsråd N/AUniversitetet i Oslo N/A
6 · The paper itself

Abstract

purposeWe hypothesized that biomarkers and dietary factors related to cardiovascular disease risk were associated with serum retinol and evaluated these potential associations in patients with suspected coronary artery disease (CAD).

methodsWe used cross-sectional data from 4116 patients hospitalised for suspected CAD. Dietary data were obtained from a subgroup of 1962 patients using a food frequency questionnaire. Potential biomarkers and dietary factors were explored using linear regression modelling adjusted for age and sex. Regression coefficients and corresponding confidence intervals (CI) are given as  % change in serum retinol per unit change in the predictors. Analyses were performed in the total population and in strata of serum retinol tertiles.

resultsIn age- and sex-adjusted models, serum creatinine (standardized β: 0.38, 95% CI [0.35, 0.42]), plasma total cysteine (0.26, [0.23, 0.29]), serum uric acid (0.30, [0.26, 0.33]) and plasma neopterin (0.22, [0.18, 0.25]) were positively associated, whereas plasma serine (- 0.15, [- 0.18, - 0.12]) and serum C-reactive protein (- 0.15, [- 0.18, - 0.12]) were inversely associated with serum retinol. When we included the significant biomarkers in a multivariate model, the model explained 33% of the variability (R

conclusionsIn patients with suspected CAD, concentrations of creatinine, cysteine and uric acid were positively associated with serum retinol. Future studies should assess whether retinol concentrations are influenced by metabolic alterations in patients at risk of cardiovascular disease.

Indexed as

BiomarkersCoronary Artery DiseaseCreatinineCross-Sectional StudiesCysteineFemaleHumansMaleMiddle AgedUric AcidVitamin ABiomarkersCreatinineCysteineUric AcidVitamin ACardiovascular diseaseCreatinineCysteineRetinolUric acidVitamin A

Identifiers

PMID31502058
PMCPMC7413901
OpenAlexW2972453834

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.