Evidence map›Paper›PMID 31501979›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2019

FGF2 and dual agonist of NCAM and FGF receptor 1, Enreptin, rescue neurite outgrowth loss in hippocampal neurons expressing mutated huntingtin proteins.

Mirolyuba Ilieva, Troels T Nielsen, Tanja Michel, Stanislava Pankratova

Abstract read
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In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mirolyuba IlievaDepartment of Psychiatry, Department of Clinical Research, University of Southern Denmark, J. B. Winsløwsvej 20, 5000, Odense, Denmark. milieva@health.sdu.dk.ORCID 0000-0002-7992-8885
Troels T NielsenDanish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Section 6911, Copenhagen, Denmark.
Tanja MichelDepartment of Psychiatry, Department of Clinical Research, University of Southern Denmark, J. B. Winsløwsvej 20, 5000, Odense, Denmark.
Stanislava PankratovaLaboratory of Neural Plasticity, Department of Neuroscience, University of Copenhagen, 2200, Copenhagen, Denmark.
University of Copenhagen · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, we developed an in vitro model of Huntington disease (HD) by transfecting primary rat hippocampal neurons with plasmids coding for m-htt exon 1 with different number of CAG repeats (18, 50 and 115) and demonstrated the influence of the length of polyQ sequence on neurite elongation. We found that exogenously applied FGF2 significantly rescued the m-htt-induced loss of neurite outgrowth. Moreover, the Enreptin peptide, an FGFR1 and NCAM dual agonist, had a similar neuritogenic effect to FGF2 in clinically relevant m-htt 50Q-expressing neurons. This study has developed an in vitro model of primary hippocampal neurons transfected with m-htt-coding vectors that is a powerful tool to study m-htt-related effects on neuronal placticity.

Indexed as

Receptor, Fibroblast Growth Factor, Type 1AnimalsDisease Models, AnimalFibroblast Growth Factor 2HippocampusHuntingtin ProteinNeural Cell Adhesion MoleculesNeuronal OutgrowthNeuronsOligopeptidesRatsRecombinant Proteinsalanyl-lysyl-threonyl-valyl-lysyl-phenylalanyl-lysineFibroblast Growth Factor 2Huntingtin ProteinNeural Cell Adhesion MoleculesOligopeptidesReceptor, Fibroblast Growth Factor, Type 1Recombinant ProteinsEnreptinFGF2Hippocampal neuronsHuntington diseaseMutant huntingtinNeurite outgrowth

Identifiers

PMID31501979
OpenAlexW2973043590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.