Evidence map›Paper›PMID 31501976›Full record

ArticleBrain imaging and behavior2020

Subcortical gray matter volumes in asthma: associations with asthma duration, control, and anxiety.

Thomas Ritz, Juliet L Kroll, Sina Aslan, Thomas Janssens, David A Khan, Amy E Pinkham, E Sherwood Brown

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Novel insights into asthma pathophysiology and pharmacological interventions: spiral of respiratory symptoms and psychiatric episodes.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  2. Asthma: Biomedical and Psychobiological Perspectives.Biopsychosocial science and medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Thomas RitzDepartment of Psychology, Southern Methodist University, P.O. Box 750442, Dallas, TX, 75275-0442, USA. tritz@smu.edu.
Juliet L KrollDepartment of Psychology, Southern Methodist University, P.O. Box 750442, Dallas, TX, 75275-0442, USA.
Sina AslanThe University of Texas Southwestern Medical Center, Dallas, TX, USA.
Thomas JanssensKU Leuven, Leuven, Belgium.
David A KhanThe University of Texas Southwestern Medical Center, Dallas, TX, USA.
Amy E PinkhamThe University of Texas at Dallas, Dallas, TX, USA.
E Sherwood BrownThe University of Texas Southwestern Medical Center, Dallas, TX, USA.
Southern Methodist University · USThe University of Texas Southwestern Medical Center · USKU Leuven · BEMagnetic Resonance Innovations (United States) · USThe University of Texas at Dallas · US

Funding

Stress, diet quality, and biological aging across the lifespanR24AG048024 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EPEL, ELISSA S., MENDES, WENDY BERRY · 2014 to 2025
$6.2M
NIA NIH HHS R24 AG048024
6 · The paper itself

Abstract

Asthma as a chronic inflammatory disease can be expected to affect central nervous system structures but little is known about subcortical structures in asthma and their potential association with illness-specific outcomes and anxiety. A total of 40 young adults (20 with asthma and 20 gender- and age-matched controls) underwent high-resolution T1-weighted MRI scan, viewed short distressing film clips, and filled in questionnaires about anxious and depressed mood, as well as asthma history, control, and catastrophizing thoughts about asthma, for those with asthma. The structural scans were processed in FSL's FIRST program to delineate subcortical structures of interest: amygdala, hippocampus, putamen, pallidum, caudate nucleus, nucleus accumbens, and thalamus. Findings showed no general reduction in subcortical gray matter volumes in asthma compared to controls. Asthma duration, asthma control, and catastrophizing of asthma and asthma attacks were negatively associated with volumes of putamen and pallidum, and to a weaker extent thalamus and amygdala, while controlling for gender, age, and corticosteroid inhaler use. In addition, stronger anxiety in response to distressing films was associated with lower volume of the pallidum, whereas general anxious and depressed mood was unrelated to subcortical structures. Thus, although there are no subcortical structural differences between young adults with asthma and healthy controls, longer asthma history, suboptimal management, and illness-related anxiety are reflected in lower gray matter volumes of subcortical structures, further emphasizing the importance of maintaining optimal asthma control.

Indexed as

AsthmaGray MatterAnxietyHumansMagnetic Resonance ImagingPutamenAnxietyAsthmaAsthma managementBasal gangliaGray matter volumeLimbic systemStructural magnetic resonance imaging

Identifiers

PMID31501976
PMCPMC8116327
OpenAlexW2972420823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.