ArticleJournal of industrial microbiology & biotechnology2019
Deletion of PHO13 improves aerobic L-arabinose fermentation in engineered Saccharomyces cerevisiae.
Article in Journal of industrial microbiology & biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Complete Utilization of the Major Carbon Sources Present in Sugar Beet Pulp Hydrolysates by the Oleaginous Red YeastsJournal of fungi (Basel, Switzerland) · 2021Article
- Transcriptomic Changes Induced by Deletion of Transcriptional RegulatorFrontiers in bioengineering and biotechnology · 2021Article
- Valorisation of pectin-rich agro-industrial residues by yeasts: potential and challenges.Applied microbiology and biotechnology · 2020Review
- Data for simultaneous fermentation of galacturonic acid and five-carbon sugars by engineeredData in brief · 2020Article
- Metabolic engineering considerations for the heterologous expression of xylose-catabolic pathways in Saccharomyces cerevisiae.PloS one · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Pentose sugars are increasingly being used in industrial applications of Saccharomyces cerevisiae. Although L-arabinose is a highlighted pentose that has been identified as next-generation biomass, arabinose fermentation has not yet undergone extensive development for industrial utilization. In this study, we integrated a heterologous fungal arabinose pathway with a deletion of PHO13 phosphatase gene. PHO13 deletion increased arabinose consumption rate and specific ethanol productivity under aerobic conditions and consequently depleted sedoheptulose by activation of the TAL1 gene. Global metabolite profiling indicated upregulation of the pentose phosphate pathway and downstream effects such as trehalose accumulation and downregulation of the TCA cycle. Our results suggest that engineering of PHO13 has ample potential for arabinose conversion to ethanol as an industrial source for biofuels.
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Registered trials
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