Evidence map›Paper›PMID 31501952›Full record

ArticleHeart and vessels2020

Regulatory T cells suppress the expression of COX-2 in vulnerable plaque.

Kai Zhang, Jing Kong, Bin Liu, Xiao Meng

Abstract read
PubMed Publisher
In one paragraph

Article in Heart and vessels, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Prostanoids in Cardiac and Vascular Remodeling.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  2. Prostaglandin EHeart and vessels · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kai ZhangKey Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, No.107, Wen Hua Xi Road, Jinan, 250012, Shandong, China.
Jing KongKey Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, No.107, Wen Hua Xi Road, Jinan, 250012, Shandong, China.
Bin LiuKey Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, No.107, Wen Hua Xi Road, Jinan, 250012, Shandong, China.
Xiao MengKey Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, No.107, Wen Hua Xi Road, Jinan, 250012, Shandong, China. jordan11502131@126.com.
Qilu Hospital of Shandong University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

the grants of the National Natural Science Foundation of China 81400195the grants of the National Natural Science Foundation of China 81425004the grants of the National Natural Science Foundation of China 81500340the International Collaboration and Exchange Program of China 81320108004the National 973 Basic Research Program of China 2013CB530703the National 973 Basic Research Program of China 2015CB553604the Program of Introducing Talents of Discipline to Universities No.B07035the State Key Program of National Natural Science of China 61331001the State Key Program of National Natural Science of China 81530014
6 · The paper itself

Abstract

COX-2 contributes to local inflammation in atherosclerotic lesions. Regulatory T cells (Tregs) enhance the stability of atherosclerotic plaques. The aim of this study was to detect the potential relationship between Tregs and COX-2 in vulnerable plaques. Thirty ApoE

Indexed as

Cell CommunicationPlaque, AtheroscleroticAdoptive TransferAnimalsCarotid Artery, CommonCarotid Artery DiseasesCoculture TechniquesCyclooxygenase 2Disease Models, AnimalDown-RegulationMaleMiceMice, Inbred C57BLMice, Knockout, ApoERAW 264.7 CellsSignal TransductionCyclooxygenase 2Ptgs2 protein, mouseAtherosclerosisCyclooxygenase-2Plaque instabilityRegulatory T cells

Identifiers

PMID31501952
OpenAlexW2972754027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.