Evidence map›Paper›PMID 31501944›Full record

ArticleJournal of mathematical biology2019

A kinetic model of T cell autoreactivity in autoimmune diseases.

M P Machado Ramos, C Ribeiro, A J Soares

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Article in Journal of mathematical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M P Machado RamosCentro de Matemática, Universidade do Minho, Guimarães, Portugal.ORCID 0000-0001-8254-3057
C RibeiroCentro de Matemática, Universidade do Minho, Guimarães, Portugal.ORCID 0000-0003-1240-8575
A J SoaresCentro de Matemática, Universidade do Minho, Braga, Portugal. ajsoares@math.uminho.pt.ORCID 0000-0003-4771-9859

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We construct a mathematical model of kinetic type in order to describe the immune system interactions in the context of autoimmune disease. The interacting populations are self-antigen presenting cells, self-reactive T cells and the set of immunosuppressive cells consisting of regulatory T cells and Natural Killer cells. The main aim of our work is to develop a qualitative analysis of the model equations and investigate the existence of biologically realistic solutions. Having this goal in mind we describe the interactions between cells during an autoimmune reaction based on biological considerations that are given in the literature and we show that the corresponding system of integro-differential equations has finite positive solutions. The asymptotic behaviour of the solution of the system is also studied. We complement our mathematical analysis with numerical simulations that study the sensitivity of the model to parameters related to proliferation of immunosuppressive cells, destruction of self-antigen presenting cells and self-reactive T cells and tolerance of SRTCs to self-antigens.

Indexed as

Immune ToleranceModels, ImmunologicalAnimalsAntigen PresentationAutoantigensAutoimmune DiseasesDisease Models, AnimalHumansKiller Cells, NaturalT-LymphocytesAutoantigensAutoimmune diseasesCellular interactionsKinetic theoryMathematical biologyModellingNon-linear ODE’s

Identifiers

PMID31501944

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.