Evidence map›Paper›PMID 31501577›Full record

ReviewNature immunology2019

The influence of the microbiome on respiratory health.

Tomasz P Wypych, Lakshanie C Wickramasinghe, Benjamin J Marsland

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04876833 (Characteristics of Intestinal Microbiome in the Progression of Early Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 370 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
370citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04876833 unknown statusnot on this mapstarted 2021, after this paper: background citation

Characteristics of Intestinal Microbiome in the Progression of Early Chronic Obstructive Pulmonary Disease

Typeobservational_patient_registrySponsorSecond Affiliated Hospital of Xi'an Jiaotong UniversityRan2021 to 2022Enrolled120ConditionsChronic Obstructive Pulmonary Disease
3 · Its place in the literature

Who cites it

370 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  15. Novel insights intomSystems · 2026
    Article
  16. Journal of pharmaceutical analysis · 2026
    Article
  17. Potassium Channels of the Airway Epithelium.Acta physiologica (Oxford, England) · 2026
    Review
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310 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tomasz P WypychDepartment of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia. tomasz.wypych@monash.edu.ORCID http://orcid.org/0000-0003-0558-7923
Lakshanie C WickramasingheDepartment of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Benjamin J MarslandDepartment of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia. benjamin.marsland@monash.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The revolution in microbiota research over the past decade has provided invaluable knowledge about the function of the microbial species that inhabit the human body. It has become widely accepted that these microorganisms, collectively called 'the microbiota', engage in networks of interactions with each other and with the host that aim to benefit both the microbial members and the mammalian members of this unique ecosystem. The lungs, previously thought to be sterile, are now known to harbor a unique microbiota and, additionally, to be influenced by microbial signals from distal body sites, such as the intestine. Here we review the role of the lung and gut microbiotas in respiratory health and disease and highlight the main pathways of communication that underlie the gut-lung axis.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaAcinetobacterAnimalsBifidobacteriumDietary SupplementsFemaleHost-Pathogen InteractionsHumansLactobacillusLungLung DiseasesMaternal ExposurePregnancyProbiotics

Identifiers

PMID31501577

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.