ArticleNature biotechnology2019
Supercooling extends preservation time of human livers.
Abstract read
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Article in Nature biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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85citing papers in PubMed
–field-weighted citation impact
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Who cites it
85 citing papers in PubMed.
- Computational Methods for Molecular Dynamics of Supercooled Water Between 200 and 273 K.Entropy (Basel, Switzerland) · 2026Review
- What we can learn from hibernators and other adapted animals about organ transplantation: mechanisms of cold resistance and enhanced regeneration.Protein & cell · 2026Article
- Article
- Automated image analysis for intracellular ice detection in monolayers by freeze-substitution.Npj imaging · 2026Article
- Alternative Preservation Strategies of Donation After Circulatory Death Hearts: Effect of Cold Ischemia Time Before Normothermic Machine Perfusion.Journal of the American Heart Association · 2026Article
- Acellular Normothermic Machine Perfusion Does not Exacerbate Acute Rejection in Rodent Vascularized Composite Allografts.Transplantation direct · 2026Article
- Protective effect of Caftaric Acid against hepatic cold ischemia/reperfusion injury in the liver.Biology direct · 2026Article
- Evaluating Isochoric Freezing as a Strategy for Storage of Red Blood Cells.Biotechnology and bioengineering · 2026Article
- Cryopreservation of biological materials: applications and economic perspectives.In vitro cellular & developmental biology. Animal · 2026Review
- Partial Freezing Enables Functional Preservation of Kidney Grafts for up to 10 Days.Research square · 2026Article
- Transforming organ donation and transplantation: challenges, innovations, and future directions.Frontiers in transplantation · 2026Review
- Revealing the potential of non-transplanted donor organs: a comparative analysis in the Eurotransplant region.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Thermodynamic Principles of Emerging Cryopreservation Technologies.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Cryopreservation Strategies to Improve Access to Organ Transplantation.Transplantation · 2026Review
- Anti-Icing Organogel Enables Quasi-Homogeneous Supercooling Preservation of Mouse Hearts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Dielectric properties of individual cryoprotective agents and cocktails VS55, M22, DP6 at subzero temperatures for cryopreservation.Scientific reports · 2025Article
- Tissue Preservation and Access: Modern Innovation in Biobanking Moving Forwards a Personalized Treatment.Journal of personalized medicine · 2025Review
- Enhancing outcomes in Langendorff-perfused rodent hearts through perfusion parameter optimization.Scientific reports · 2025Article
- Engineered supercooling systems for enhanced long-term preservation of large-volume red blood cells in commercial blood bags.Journal of biological engineering · 2025Article
- Designer Organs: Ethical Genetic Modifications in the Era of Machine Perfusion.Annual review of biomedical engineering · 2025Review
25 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors.
Reinier J de VriesCenter for Engineering in Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
Shannon N TessierCenter for Engineering in Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
Peony D BanikCenter for Engineering in Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
Sonal NagpalCenter for Engineering in Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
Stephanie E J CroninCenter for Engineering in Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
Sinan OzerCenter for Engineering in Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
Ehab O A HafizCenter for Engineering in Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1551-4309
Thomas M van GulikDepartment of Surgery, University of Amsterdam, Amsterdam, the Netherlands.
Martin L YarmushCenter for Engineering in Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
James F MarkmannCenter for Engineering in Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
Mehmet TonerCenter for Engineering in Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
Heidi YehCenter for Engineering in Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
Korkut UygunCenter for Engineering in Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA. kuygun@mgh.harvard.edu.
Funding
High subzero preservation of liver for transplantationR01DK114506 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI TONER, MEHMET, UYGUN, KORKUT · 2017 to 2025
$4.4MMetabolic Modeling for Cadaveric Organ ResuscitationR01DK096075 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI UYGUN, KORKUT, YEH, HEIDI · 2012 to 2022
$3.9MExpanding the Liver Transplant Organ Pool through Ex Vivo Liver PerfusionR01DK107875 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MARKMANN, JAMES FRANCIS, UYGUN, KORKUT · 2016 to 2020
$2.8MHigh subzero heart preservation: from zebrafish to mammalsR01HL157803 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Shannon Noella Tessier · 2021 to 2026
$2.8MWhole heart suspended animation: leveraging the zebrafish to solve the organ shortageR00HL143149 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI TESSIER, SHANNON NOELLA · 2021 to 2023
$747kEquilibrium sub-cooling for non-frozen banking of human liversR21EB023031 · NIBIB · SYLVATICA BIOTECH, INC. · PI TAYLOR, MICHAEL JOHN · 2016 to 2017
$571kWhole heart suspended animation: leveraging the zebrafish to solve the organ shortageK99HL143149 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI TESSIER, SHANNON NOELLA · 2019 to 2020
$215kNHLBI NIH HHS K99 HL143149NHLBI NIH HHS R00 HL143149NHLBI NIH HHS R01 HL157803NIBIB NIH HHS R21 EB023031NIDDK NIH HHS R01 DK096075NIDDK NIH HHS R01 DK107875NIDDK NIH HHS R01 DK114506
Abstract
The inability to preserve vascular organs beyond several hours contributes to the scarcity of organs for transplantation
Indexed as
Cold TemperatureHumansLiverOrgan PreservationOrgan Preservation SolutionsPerfusionTissue SurvivalOrgan Preservation Solutions
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.