ArticleNature nanotechnology2019
A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing.
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Article in Nature nanotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers.
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161citing papers in PubMed
15.2field-weighted citation impact, top 1% of its field
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Who cites it
161 citing papers in PubMed, 353 citations in OpenAlex.
- CRISPR RNP-Mediated Transgene-Free Genome Editing in Plants: Advances, Challenges and Future Directions for Tree Species.Plant, cell & environment · 2026Review
- Chemically modified CRISPR enzymes for multi-organ genome editingbioRxiv : the preprint server for biology · 2026Article
- Nanoengineering Systems for Gene Therapy: Mechanisms, Modalities, and Future Directions.International journal of molecular sciences · 2026Review
- Topical application of Cas9 ribonucleoproteins inhibits corneal neovascularization in a mouse model of alkali burn injury.Gene therapy · 2026Article
- A Cryoprotectant-Compatible Nanoporous Platform for Stable and Scalable Delivery of Biopharmaceuticals.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Non-viral delivery of genome-editing tools for treatment of genetic disorders.Acta pharmaceutica Sinica. B · 2026Review
- Bipolar CD4-targeted dual-DARPin-55/57 lipid nanoparticle enables efficient CRISPR/Cas-mediated HIV-1 DNA excision and reactivation blockade in latent CD4 T cell lines.Materials today. Bio · 2026Article
- FAST-CRISPR: Fusogenic Association and Secured Transfection of CRISPR/Cas9 Ribonucleoproteins Using Lipid-Silica Hybrid Nanoparticles for Therapeutic Genome Editing.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Nature Inspired Delivery Vehicles for CRISPR-Based Genome Editing.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Targeting MGAT4A-Mediated N-Glycosylation as a Therapeutic Strategy to Inhibit Glioblastoma Stem Cell Invasion.Exploration (Beijing, China) · 2026Article
- Next-generation CRISPR systems and advanced delivery paradigms for precision crop improvement: a comparative case study in sugar beet (Frontiers in plant science · 2026Review
- Suppression of HBV replication and expression by CRISPR/Cas9 ribonucleoproteins.Antiviral research · 2026Article
- From molecular correction to functional rescue: delivery, tissue state, and immunobiology as the principal constraints on dystrophin-restoring therapy in Duchenne muscular dystrophy.Frontiers in pharmacology · 2026Review
- Nanomaterials in gene therapy and genome editing: challenges and emerging directions.Journal of nanobiotechnology · 2025Review
- Therapeutic mRNA delivery of CRISPR-Cas9 to the trabecular meshwork reverses ocular hypertension in myocilin glaucoma.Molecular therapy. Methods & clinical development · 2025Article
- Brain-wide Genome Editing via STEP-RNPs for Treatment of Angelman Syndrome.bioRxiv : the preprint server for biology · 2025Article
- Innovative gene engineering and drug delivery systems for dendritic cells in cancer immunotherapy.Journal of biomedical science · 2025Review
- A multistep platform identifies spleen-tropic lipid nanoparticles for in vivo T cell-targeted delivery of gene-editing proteins.Science advances · 2025Article
- Mechanotransduction-Epigenetic Coupling in Pulmonary Regeneration: Multifunctional Bioscaffolds as Emerging Tools.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Controlling CRISPR-Cas9 genome editing in human cells using a molecular glue degrader.Molecular therapy. Nucleic acids · 2025Article
101 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 1 institution in 1 country.
Guojun ChenDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Amr A AbdeenWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA.
Yuyuan WangDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Pawan K ShahiDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Samantha RobertsonDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA.
Ruosen XieDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Masatoshi SuzukiDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0003-3253-0711
Bikash R PattnaikDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-5385-358X
Krishanu SahaWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA. ksaha@wisc.edu.ORCID http://orcid.org/0000-0003-2837-0858
Shaoqin GongDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, USA. shaoqingong@wisc.edu.ORCID http://orcid.org/0000-0001-9447-2938
University of Wisconsin–Madison · US
Funding
Assembly of Novel Gene Editing Particles to Understand Genome Surgery in Patient-Derived CellsR35GM119644 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SAHA, KRISHANU · 2016 to 2025
$4.0MTargeting PERK: An Endothelium-Protective Stent-Free Strategy for Mitigation of Intimal Hyperplasia After Vascular SurgeryR01HL143469 · NHLBI · UNIVERSITY OF VIRGINIA · PI GONG, SHAOQIN -, GUO, LIANWANG · 2018 to 2021
$2.4MEnabling Nanoplatforms for Targeted in vivo Delivery of CRISPR/Cas9 Ribonucleoproteins in the BrainUG3NS111688 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI EMBORG, MARINA, GONG, SHAOQIN - · 2018 to 2020
$2.3MDevelopment of unimolecular nanoparticle-mediated periadventitial drug delivery system for sustained and targeted inhibition of intimal hyperplasia following open vascular reconstructionR01HL129785 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GUO, LIANWANG, KENT, K CRAIG · 2016 to 2019
$2.0MMuscle stem cells: New ALS growth factor therapy and disease modelR01NS091540 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI SUZUKI, MASATOSHI · 2015 to 2019
$1.7MMolecular Therapies for Lebers Congenital Amaurosis Caused by KCNJ13 MutationsR01EY024995 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI PATTNAIK, BIKASH RANJAN · 2015 to 2018
$1.5MNEI NIH HHS R01 EY024995NHLBI NIH HHS R01 HL129785NHLBI NIH HHS R01 HL143469NIGMS NIH HHS R35 GM119644NINDS NIH HHS R01 NS091540NINDS NIH HHS UG3 NS111688
Abstract
Delivery technologies for the CRISPR-Cas9 (CRISPR, clustered regularly interspaced short palindromic repeats) gene editing system often require viral vectors, which pose safety concerns for therapeutic genome editing
Indexed as
CRISPR-Cas SystemsGene EditingAnimalsCRISPR-Associated Protein 9GlutathioneHEK293 CellsHumansMiceNanocapsulesPolymersRNA, Guide, CRISPR-Cas SystemsCRISPR-Associated Protein 9GlutathioneNanocapsulesPolymersRNA, Guide, CRISPR-Cas Systems
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.