Evidence map›Paper›PMID 31501459›Full record

ArticleScientific reports2019

Silver ions promote blebs growth in U251 glioblastoma cell by activating nonselective cationic currents.

Francesco Ragonese, Lorenzo Monarca, Federica Bastioli, Cataldo Arcuri, Loretta Mancinelli, Bernard Fioretti

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. KCa3.1 mediates radioresistance of silver nanoparticles in human glioblastoma cells.Pflugers Archiv : European journal of physiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Francesco RagoneseDepartment of Chemistry, Biology and Biotechnologies, Via Elce di Sotto 8, University of Perugia, Perugia, Italy.
Lorenzo MonarcaDepartment of Chemistry, Biology and Biotechnologies, Via Elce di Sotto 8, University of Perugia, Perugia, Italy.
Federica BastioliDepartment of Chemistry, Biology and Biotechnologies, Via Elce di Sotto 8, University of Perugia, Perugia, Italy.
Cataldo ArcuriDepartment of Experimental Medicine, Piazzale Gambuli 1, University of Perugia, Perugia, Italy.
Loretta MancinelliDepartment of Chemistry, Biology and Biotechnologies, Via Elce di Sotto 8, University of Perugia, Perugia, Italy.
Bernard FiorettiDepartment of Chemistry, Biology and Biotechnologies, Via Elce di Sotto 8, University of Perugia, Perugia, Italy. bernard.fioretti@unipg.it.
University of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is the most common and aggressive human brain cancer with low prognosis and therefore the discovery of new anticancer agents is needful. Sulfydryl reagents, such as silver, have been shown to induce membrane vesiculation in several cellular models through a mechanism that has not been yet completely clarified. Using U251 glioblastoma cells, we observed that silver induced irreversible bleb formation of the plasma membrane. This morphological event was anticipated by an increase of intracellular Ca

Indexed as

CalciumCell Line, TumorCell MembraneCell ProliferationElectrophysiological PhenomenaGlioblastomaHumansHydrostatic PressureIntracellular SpaceSilverSodiumCalciumSilverSodium

Identifiers

PMID31501459
PMCPMC6733836
OpenAlexW2972580600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.