ArticleNature communications2019
Large-scale parallelization of nanomechanical mass spectrometry with weakly-coupled resonators.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Mass and Stiffness Deconvolution in Nanomechanical Resonators for Precise Mass Measurement and In Vivo Biosensing.ACS nano · 2024Article
- Flexural-Mode Piezoelectric Resonators: Structure, Performance, and Emerging Applications in Physical Sensing Technology, Micropower Systems, and Biomedicine.Sensors (Basel, Switzerland) · 2024Review
- Graphene nano-electromechanical mass sensor with high resolution at room temperature.iScience · 2023Article
- High-throughput determination of dry mass of single bacterial cells by ultrathin membrane resonators.Communications biology · 2022Article
- Protein adsorption by nanomechanical mass spectrometry: Beyond the real-time molecular weighting.Frontiers in molecular biosciences · 2022Review
- Dual-Resonator-Based (DRB) and Multiple-Resonator-Based (MRB) MEMS Sensors: A Review.Micromachines · 2021Review
- Reaching silicon-based NEMS performances with 3D printed nanomechanical resonators.Nature communications · 2021Article
- Optomechanical detection of vibration modes of a single bacterium.Nature nanotechnology · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanomechanical mass spectrometry is a recent technological breakthrough that enables the real-time analysis of single molecules. In contraposition to its extreme mass sensitivity is a limited capture cross-section that can hinder measurements in a practical setting. Here we show that weak-coupling between devices in resonator arrays can be used in nanomechanical mass spectrometry to parallelize the measurement. This coupling gives rise to asymmetric amplitude peaks in the vibrational response of a single nanomechanical resonator of the array, which coincide with the natural frequencies of all other resonators in the same array. A rigorous theoretical model is derived that explains the physical mechanisms and describes the practical features of this parallelization. We demonstrate the significance of this parallelization through inertial imaging of analytes adsorbed to all resonators of an array, with the possibility of simultaneously detecting resonators placed at distances a hundred times larger than their own physical size.
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Registered trials
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