Evidence map›Paper›PMID 31501349›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Immunogenicity of a rheumatoid arthritis protective sequence when acquired through microchimerism.

Sami B Kanaan, Oyku Sensoy, Zhen Yan, Vijayakrishna K Gadi, Michael L Richardson, J Lee Nelson

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

  1. Identifying Key Questions and Challenges in Microchimerism Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  2. Review
  3. Review
  4. The Microchimerism Literature Atlas.Bioinformatics and biology insights · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Umbilical Cord Maternal Microchimerism in Normal and Preeclampsia Pregnancies.Reproductive sciences (Thousand Oaks, Calif.) · 2023
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sami B KanaanClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109; skanaan@fredhutch.org.
Oyku SensoyClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
Zhen YanClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
Vijayakrishna K GadiClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
Michael L RichardsonDepartment of Radiology, University of Washington, Seattle, WA 98195.
J Lee NelsonClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
Fred Hutch Cancer Center · USUniversity of Washington · US

Funding

ALLOIMMUNITY IN AUTO IMMUNE DISEASER01AI045659 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NELSON, J. LEE · 1999 to 2009
$3.4M
Microchimerism as AlloImmunityR01HL117737 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NELSON, J. LEE · 2014 to 2018
$2.4M
NHLBI NIH HHS R01 HL117737NIAID NIH HHS R01 AI045659
6 · The paper itself

Abstract

HLA class II genes provide the strongest genetic contribution to rheumatoid arthritis (RA).

Indexed as

AdultAllelesAllogeneic CellsArthritis, RheumatoidChimerismCross ReactionsEpitopesFemaleGenetic Predisposition to DiseaseHLA-DQ AntigensHLA-DRB1 ChainsHumansT-LymphocytesEpitopesHLA-DQ AntigensHLA-DRB1 ChainsDERAAHLAmicrochimerismnoninherited genetic riskrheumatoid arthritis

Identifiers

PMID31501349
PMCPMC6765309
OpenAlexW2973083980

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.