Evidence map›Paper›PMID 31501343›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Distinct intraspecies virulence mechanisms regulated by a conserved transcription factor.

James P R Connolly, Nicky O'Boyle, Natasha C A Turner, Douglas F Browning, Andrew J Roe

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. DistinctbioRxiv : the preprint server for biology · 2024
    Article
  8. Article
  9. Article
  10. Distinct ecological fitness factors coordinated by a conservedProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Article
  12. Control of resistance against bacteriophage killing by a metabolic regulator in meningitis-associatedProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  13. Article
  14. Article
  15. Microbial Musings - October 2021.Microbiology (Reading, England) · 2021
    Article
  16. Article
  17. Small RNA Regulation of Virulence in PathogenicFrontiers in cellular and infection microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James P R ConnollyInstitute of Infection, Immunity and Inflammation, University of Glasgow, G12 8TA Glasgow, United Kingdom; james.connolly2@newcastle.ac.uk andrew.roe@glasgow.ac.uk.
Nicky O'BoyleInstitute of Infection, Immunity and Inflammation, University of Glasgow, G12 8TA Glasgow, United Kingdom.
Natasha C A TurnerInstitute of Infection, Immunity and Inflammation, University of Glasgow, G12 8TA Glasgow, United Kingdom.
Douglas F BrowningInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, B15 2TT Birmingham, United Kingdom.
Andrew J RoeInstitute of Infection, Immunity and Inflammation, University of Glasgow, G12 8TA Glasgow, United Kingdom; james.connolly2@newcastle.ac.uk andrew.roe@glasgow.ac.uk.ORCID 0000-0003-3698-6134

Funding

Biotechnology and Biological Sciences Research Council BB/M029646/1Biotechnology and Biological Sciences Research Council BB/R006539/1Wellcome Trust 204820/Z/16/Z
6 · The paper itself

Abstract

Tailoring transcriptional regulation to coordinate the expression of virulence factors in tandem with the core genome is a hallmark of bacterial pathogen evolution. Bacteria encode hundreds of transcription factors forming the base-level control of gene regulation. Moreover, highly homologous regulators are assumed to control conserved genes between members within a species that harbor the same genetic targets. We have explored this concept in 2

Indexed as

BacteriaEnterohemorrhagic Escherichia coliEscherichia coliEscherichia coli InfectionsEscherichia coli ProteinsFimbriae, BacterialGene Expression Regulation, BacterialTranscription FactorsType III Secretion SystemsUropathogenic Escherichia coliVirulenceVirulence FactorsEscherichia coli ProteinsTranscription FactorsType III Secretion SystemsVirulence Factorsgene expressionnicheregulationtype 1 fimbriaetype 3 secretion

Identifiers

PMID31501343
PMCPMC6765310

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.