ArticleProceedings of the National Academy of Sciences of the United States of America2019
Development and utilization of human decidualization reporter cell line uncovers new modulators of female fertility.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 78 citations in OpenAlex.
- Decidualization potential of endometrial mesenchymal stem cells and their role in reproductive health.Reproductive biology and endocrinology : RB&E · 2026Review
- Serum response factor is essential for endometrial function and prevention of inflammatory fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- SALL1 Is an Orchestrator of Uterine Receptivity in Part via Titration of Estrogen Signaling.Endocrinology · 2025Article
- Cell type and region-specific transcriptional changes in the endometrium of women with RIF identify potential treatment targets.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Monoamine oxidases activity maintains endometrial monoamine homeostasis and participates in embryo implantation and development.BMC biology · 2024Article
- Progesterone inactivation in decidual stromal cells: A mechanism for inflammation-induced parturition.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Neu5Gc regulates decidual macrophages leading to abnormal embryo implantation.Genes and immunity · 2024Article
- Article
- Development of an in-vitro high-throughput screening system to identify modulators of genitalia development.PNAS nexus · 2023Article
- An IGF1-expressing endometrial stromal cell population is associated with human decidualization.BMC biology · 2022Article
- The Regulators of Human Endometrial Stromal Cell Decidualization.Biomolecules · 2022Review
- Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization.JCI insight · 2021Article
- Investigation of infertility using endometrial organoids.Reproduction (Cambridge, England) · 2021Review
- Capture and metabolomic analysis of the human endometrial epithelial organoid secretome.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- "All-In-One" Genetic Tool Assessing Endometrial Receptivity for Personalized Screening of Female Sex Steroid Hormones.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Failure of embryo implantation accounts for a significant percentage of female infertility. Exquisitely coordinated molecular programs govern the interaction between the competent blastocyst and the receptive uterus. Decidualization, the rapid proliferation and differentiation of endometrial stromal cells into decidual cells, is required for implantation. Decidualization defects can cause poor placentation, intrauterine growth restriction, and early parturition leading to preterm birth. Decidualization has not yet been systematically studied at the genetic level due to the lack of a suitable high-throughput screening tool. Herein we describe the generation of an immortalized human endometrial stromal cell line that uses yellow fluorescent protein under the control of the prolactin promoter as a quantifiable visual readout of the decidualization response (hESC-PRLY cells). Using this cell line, we performed a genome-wide siRNA library screen, as well as a screen of 910 small molecules, to identify more than 4,000 previously unrecognized genetic and chemical modulators of decidualization. Ontology analysis revealed several groups of decidualization modulators, including many previously unappreciated transcription factors, sensory receptors, growth factors, and kinases. Expression studies of hits revealed that the majority of decidualization modulators are acutely sensitive to ovarian hormone exposure. Gradient treatment of exogenous factors was used to identify EC
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