ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Disentangling Hippocampal and Amygdala Contribution to Human Anxiety-Like Behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Cortical-limbic circuit dynamics of approach-avoidance conflict in humans.Nature communications · 2026Article
- Human approach-avoidance conflict behaviour relates to transdiagnostic psychiatric symptom dimensions.Translational psychiatry · 2026Article
- Scaling of Ventral Hippocampal Activity during Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hippocampal damage disrupts the latent decision-making processes underlying approach-avoidance conflict processing in humans.PLoS biology · 2025Article
- The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat.Communications biology · 2024Article
- Anxiety and depression: A top-down, bottom-up model of circuit function.Annals of the New York Academy of Sciences · 2023Review
- Effect of prenatal stress and extremely low-frequency electromagnetic fields on anxiety-like behavior in female rats: With an emphasis on prefrontal cortex and hippocampus.Brain and behavior · 2023Article
- Closed-loop enhancement and neural decoding of cognitive control in humans.Nature biomedical engineering · 2023Article
- Preclinical and clinical evidence on the approach-avoidance conflict evaluation as an integrative tool for psychopathology.Epidemiology and psychiatric sciences · 2022Article
- Prefrontal cortex interactions with the amygdala in primates.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Cross-species anxiety tests in psychiatry: pitfalls and promises.Molecular psychiatry · 2022Review
- Dysregulation in Sphingolipid Signaling Pathways is Associated With Symptoms and Functional Connectivity of Pain Processing Brain Regions in Provoked Vestibulodynia.The journal of pain · 2021Observational
- Neutrophil-specific deletion of Syk results in recruitment-independent stabilization of the barrier and a long-term improvement in cognitive function after traumatic injury to the developing brain.Neurobiology of disease · 2021Article
- Maternal L-thyroxine treatment during lactation affects learning and anxiety-like behaviors but not spatial memory in adult rat progeny.Pharmacological reports : PR · 2021Article
- Perirhinal Cortex is Involved in the Resolution of Learned Approach-Avoidance Conflict Associated with Discrete Objects.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Article
- Controllability over stressor decreases responses in key threat-related brain areas.Communications biology · 2021Article
- Hippocampal Representation of Threat Features and Behavior in a Human Approach-Avoidance Conflict Anxiety Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Predictors of risky foraging behaviour in healthy young people.Nature human behaviour · 2020Article
- The Role of Amygdala in Self-Conscious Emotions in a Patient With Acquired Bilateral Damage.Frontiers in neuroscience · 2020Article
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5 authors.
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Abstract
Anxiety comprises a suite of behaviors to deal with potential threat and is often modeled in approach-avoidance conflict tasks. Collectively, these tests constitute a predominant preclinical model of anxiety disorder. A body of evidence suggests that both ventral hippocampus and amygdala lesions impair anxiety-like behavior, but the relative contribution of these two structures is unclear. A possible reason is that approach-avoidance conflict tasks involve a series of decisions and actions, which may be controlled by distinct neural mechanisms that are difficult to disentangle from behavioral readouts. Here, we capitalize on a human approach-avoidance conflict test, implemented as computer game, that separately measures several action components. We investigate three patients of both sexes with unspecific unilateral medial temporal lobe (MTL) damage, one male with selective bilateral hippocampal (HC), and one female with selective bilateral amygdala lesions, and compare them to matched controls. MTL and selective HC lesions, but not selective amygdala lesions, increased approach decision when possible loss was high. In contrast, MTL and selective amygdala lesions, but not selective HC lesions, increased return latency. Additionally, selective HC and selective amygdala lesions reduced approach latency. In a task targeted at revealing subjective assumptions about the structure of the computer game, MTL and selective HC lesions impacted on reaction time generation but not on the subjective task structure. We conclude that deciding to approach reward under threat relies on hippocampus but not amygdala, whereas vigor of returning to safety depends on amygdala but not on hippocampus.
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