Evidence map›Paper›PMID 31501280›Full record

ArticleJournal of bacteriology2019

Conceptual Model of Biofilm Antibiotic Tolerance That Integrates Phenomena of Diffusion, Metabolism, Gene Expression, and Physiology.

Philip S Stewart, Ben White, Laura Boegli, Timothy Hamerly, Kerry S Williamson, Michael J Franklin, Brian Bothner, Garth A James, Steve Fisher, Francisco G Vital-Lopez and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 81 citations in OpenAlex.

  1. Review
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  3. Food science and biotechnology · 2026
    Review
  4. mSystems · 2026
    Article
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  17. Heterogenous biofilm mass-transport model replicates periphery sequestration of antibiotics inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Philip S StewartCenter for Biofilm Engineering, Montana State University, Bozeman, Montana, USA phil_s@montana.edu.ORCID 0000-0001-7773-8570
Ben WhiteCenter for Biofilm Engineering, Montana State University, Bozeman, Montana, USA.
Laura BoegliCenter for Biofilm Engineering, Montana State University, Bozeman, Montana, USA.
Timothy HamerlyCenter for Biofilm Engineering, Montana State University, Bozeman, Montana, USA.
Kerry S WilliamsonCenter for Biofilm Engineering, Montana State University, Bozeman, Montana, USA.
Michael J FranklinCenter for Biofilm Engineering, Montana State University, Bozeman, Montana, USA.
Brian BothnerCenter for Biofilm Engineering, Montana State University, Bozeman, Montana, USA.
Garth A JamesCenter for Biofilm Engineering, Montana State University, Bozeman, Montana, USA.
Steve FisherCenter for Biofilm Engineering, Montana State University, Bozeman, Montana, USA.
Francisco G Vital-LopezDepartment of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland, USA.
Anders WallqvistDepartment of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland, USA.ORCID 0000-0002-9775-7469
Montana State University · USTelemedicine & Advanced Technology Research Center · US

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Jeffrey Good · 2012 to 2026
$60.0M
Resuscitation of P. aeruginosa biofilm cells from dormancyR01AI113330 · NIAID · MONTANA STATE UNIVERSITY - BOZEMAN · PI FRANKLIN, MICHAEL J. · 2014 to 2018
$1.6M
Genetic and physiological analyses of P. aeruginosa dormancy factorsR21AI140163 · NIAID · MONTANA STATE UNIVERSITY - BOZEMAN · PI FRANKLIN, MICHAEL J. · 2018 to 2019
$391k
NIAID NIH HHS R01 AI113330NIAID NIH HHS R21 AI140163NIGMS NIH HHS P20 GM103474
6 · The paper itself

Abstract

Transcriptomic, metabolomic, physiological, and computational modeling approaches were integrated to gain insight into the mechanisms of antibiotic tolerance in an

Indexed as

Drug Resistance, BacterialAnti-Bacterial AgentsBiofilmsCiprofloxacinDiffusionGene ExpressionModels, BiologicalOxygenPseudomonas aeruginosaStress, PhysiologicalAnti-Bacterial AgentsCiprofloxacinOxygenantibiotic resistancebiofilmsphysiologystarvationstress response

Identifiers

PMID31501280
PMCPMC6805107
OpenAlexW2972125680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.