Evidence map›Paper›PMID 31501142›Full record

ArticleAntimicrobial agents and chemotherapy2019

Novel Inducers of the Expression of Multidrug Efflux Pumps That Trigger

Pablo Laborda, Manuel Alcalde-Rico, Paula Blanco, José Luis Martínez, Sara Hernando-Amado

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Role of bacterial multidrug efflux pumps during infection.World journal of microbiology & biotechnology · 2024
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Oxidative Stress Response inPathogens (Basel, Switzerland) · 2021
    Review
  16. Review
  17. Dynamic Adaptive Response ofAntibiotics (Basel, Switzerland) · 2021
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pablo Laborda *Centro Nacional de Biotecnología, CSIC, Madrid, Spain.
Manuel Alcalde-Rico *Centro Nacional de Biotecnología, CSIC, Madrid, Spain.
Paula BlancoCentro Nacional de Biotecnología, CSIC, Madrid, Spain.
José Luis MartínezCentro Nacional de Biotecnología, CSIC, Madrid, Spain jlmtnez@cnb.csic.es shernando@cnb.csic.es.ORCID 0000-0001-8813-7607
Sara Hernando-AmadoCentro Nacional de Biotecnología, CSIC, Madrid, Spain jlmtnez@cnb.csic.es shernando@cnb.csic.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study of the acquisition of antibiotic resistance (AR) has mainly focused on inherited processes, namely, mutations and acquisition of AR genes. However, inducible, noninheritable AR has received less attention, and most information in this field derives from the study of antibiotics as inducers of their associated resistance mechanisms. Less is known about nonantibiotic compounds or situations that can induce AR during infection. Multidrug resistance efflux pumps are a category of AR determinants characterized by the tight regulation of their expression. Their contribution to acquired AR relies in their overexpression. Here, we analyzed potential inducers of the expression of the chromosomally encoded

Indexed as

Drug Resistance, Multiple, BacterialGene Expression Regulation, BacterialGenes, MDRHigh-Throughput Screening AssaysMembrane Transport ProteinsPseudomonas aeruginosaReal-Time Polymerase Chain ReactionMembrane Transport ProteinsBiologMDR efflux pumpsPseudomonas aeruginosatransient antibiotic resistance

Identifiers

PMID31501142
PMCPMC6811419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.