Evidence map›Paper›PMID 31501133›Full record

ArticleBMJ open2019

Protocol for a multisite randomised trial of Hand-Arm Bimanual Intensive Training Including Lower Extremity training for children with bilateral cerebral palsy: HABIT-ILE Australia.

Leanne Sakzewski, Yannick Bleyenheuft, Roslyn N Boyd, Iona Novak, Catherine Elliott, Sarah Reedman, Cathy Morgan, Kerstin Pannek, Jurgen Fripp, Prue Golland and 3 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05740605 (Implementation of a HABIT-ILE at Home Intervention for Children With Bilateral Cerebral Palsy), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05740605 narecruitingnot on this mapstarted 2023, after this paper: background citation

Implementation of a HABIT-ILE at Home Intervention for Children With Bilateral Cerebral Palsy: a Non-inferiority Randomized Controlled Trial

TypeinterventionalSponsorUniversité Catholique de LouvainRan2023 to 2027Enrolled48ConditionsCerebral PalsyArmsHand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE), Hand-Arm Bimanual Intensive Therapy Including Lower Extremities at home, Follow-up Hand-Arm Bimanual Intensive Therapy Including Lower Extremities, Usual Care
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Mirror movement disorder rehabilitation after epilepsy: A case report and video presentation.Turkish journal of physical medicine and rehabilitation · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Leanne SakzewskiQueensland Cerebral Palsy and Rehabilitation Research Centre, The Faculty of Medicine, University of Queensland, South Brisbane, Queensland, Australia l.sakzewski1@uq.edu.au.ORCID 0000-0001-5395-544X
Yannick BleyenheuftInstitute of Neuroscience, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.
Roslyn N BoydQueensland Cerebral Palsy and Rehabilitation Research Centre, The Faculty of Medicine, University of Queensland, South Brisbane, Queensland, Australia.
Iona NovakCerebral Palsy Alliance, Brookvale, New South Wales, Australia.
Catherine ElliottSchool of Occupational Therapy and Social Work, Curtin University, Perth, Western Australia, Australia.
Sarah ReedmanQueensland Cerebral Palsy and Rehabilitation Research Centre, The Faculty of Medicine, University of Queensland, South Brisbane, Queensland, Australia.
Cathy MorganCerebral Palsy Alliance, Brookvale, New South Wales, Australia.
Kerstin PannekCSIRO Health and Biosecurity, CSIRO Australian e-Health Research Centre, Herston, Queensland, Australia.
Jurgen FrippCSIRO Health and Biosecurity, CSIRO Australian e-Health Research Centre, Herston, Queensland, Australia.
Prue GollandCerebral Palsy Alliance, Brookvale, New South Wales, Australia.
David RowellFaculty of Business, Economics and Law, University of Queensland, Wooloongabba, Queensland, Australia.
Mark ChatfieldQueensland Cerebral Palsy and Rehabilitation Research Centre, The Faculty of Medicine, University of Queensland, South Brisbane, Queensland, Australia.
Robert Stuart WareMenzies Health Institute Queensland, Griffith University, Nathan, Queensland, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChildren with bilateral cerebral palsy often experience difficulties with posture, gross motor function and manual ability, impacting independence in daily life activities, participation and quality of life (QOL). Hand-Arm Bimanual Intensive Training Including Lower Extremity (HABIT-ILE) is a novel intensive motor intervention integrating upper and lower extremity training. This study aimed to compare HABIT-ILE to usual care in a large randomised controlled trial (RCT) in terms of gross motor function, manual ability, goal attainment, walking endurance, mobility, self-care and QOL. A within-trial cost-utility analysis will be conducted to synthesise costs and benefits of HABIT-ILE compared with usual care. METHODS AND ANALYSIS: 126 children with bilateral cerebral palsy aged 6-16 years will be recruited across three sites in Australia. Children will be stratified by site and Gross Motor Function Classification System and randomised using concealed allocation to either receiving HABIT-ILE immediately or being waitlisted for 26 weeks. HABIT-ILE will be delivered in groups of 8-12 children, for 6.5 hours per day for 10 days (total 65 hours, 2 weeks). Outcomes will be assessed at baseline, immediately following intervention, and then retention of effects will be tested at 26 weeks. Primary outcomes will be the Gross Motor Function Measure and ABILHAND-Kids. Secondary outcomes will be brain structural integrity, walking endurance, bimanual hand performance, self-care, mobility, performance and satisfaction with individualised goals, and QOL. Analyses will follow standard principles for RCTs using two-group comparisons on all participants on an intention-to-treat basis. Comparisons between groups for primary and secondary outcomes will be conducted using regression models. ETHICS AND DISSEMINATION: Ethics approval has been granted by the Medical Research Ethics Committee of Children's Health Queensland Hospital and the Health Service Human Research Ethics Committee (HREC/17/QRCH/282) of The University of Queensland (2018000017/HREC/17/QRCH/2820), and The Cerebral Palsy Alliance Ethics Committee (2018_04_01/HREC/17/QRCH/282). TRIAL REGISTRATION NUMBER: ACTRN12618000164291.

Indexed as

Cerebral PalsyPhysical Therapy ModalitiesQuality of LifeActivities of Daily LivingAdolescentChildExercise TherapyFemaleHumansLower ExtremityMaleMotor ActivityMotor SkillsOutcome and Process Assessment, Health CareRandomized Controlled Trials as TopicUpper Extremitycerebral palsychildrengross motor functionhand–arm bimanual intensive training including lower extremitymanual abilityrandomised controlled trial

Identifiers

PMID31501133
PMCPMC6738737

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.