ArticleNeurobiology of aging2019
Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Regional cerebral arterial elasticity is associated with cardiovascular health in cognitively healthy older adults.bioRxiv : the preprint server for biology · 2026Article
- Region-specific associations between cerebral arterial elasticity and grey matter volume: Evidence for lateral prefrontal vulnerability.bioRxiv : the preprint server for biology · 2025Article
- Effects of Aging, Estimated Fitness, and Cerebrovascular Status on White Matter Microstructural Health.Human brain mapping · 2025Article
- Increased arterial stiffness is associated with poorer social cognition in older age.Scientific reports · 2025Article
- The cognitive neuroscience and neurocognitive rehabilitation of dance.BMC neuroscience · 2024Review
- Neurovascular mechanisms of cognitive aging: Sex-related differences in the average progression of arteriosclerosis, white matter atrophy, and cognitive decline.Neurobiology of disease · 2024Article
- Effects of the royal jelly consumption on post-stroke complications in patients with ischemic stroke: results of a randomized controlled trial.Frontiers in nutrition · 2023Article
- Getting Fit to Counteract Cognitive Aging: Evidence and Future Directions.Physiology (Bethesda, Md.) · 2022Review
- Characterising activity and diet compositions for dementia prevention: protocol for the ACTIVate prospective longitudinal cohort study.BMJ open · 2022Article
- A healthy mind in a healthy body: Effects of arteriosclerosis and other risk factors on cognitive aging and dementia.The psychology of learning and motivation · 2022Article
- Coronary artery disease and its impact on the pulsatile brain: A functional NIRS study.Human brain mapping · 2021Article
- Indexing cerebrovascular health using near-infrared spectroscopy.Scientific reports · 2021Article
- Age-related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review.Psychophysiology · 2021Review
- The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review.Molecules (Basel, Switzerland) · 2021Review
- Dietary Structure and Nutritional Status of Chinese Beekeepers: Demographic Health Survey.JMIR public health and surveillance · 2021Article
- Royal Jelly as an Intelligent Anti-Aging Agent-A Focus on Cognitive Aging and Alzheimer's Disease: A Review.Antioxidants (Basel, Switzerland) · 2020Review
- Age-related differences in functional brain network segregation are consistent with a cascade of cerebrovascular, structural, and cognitive effects.Network neuroscience (Cambridge, Mass.) · 2020Article
- Cerebral Arterial Pulsatility and Global White Matter Microstructure Impact Spatial Working Memory in Older Adults With and Without Cardiovascular Risk Factors.Frontiers in aging neuroscience · 2020Article
- Assessment of cerebrovascular development and intraventricular hemorrhages in preterm infants with optical measures of the brain arterial pulse wave.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
Decline in fluid abilities in normal aging is associated with increased white matter lesions, measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs are particularly evident in hypertensive older adults, suggesting vascular involvement. However, because hypertension is assessed systemically, the specific role of cerebral arterial stiffening in WMSAs has yet to be demonstrated. In 93 cognitively normal adults (aged 18-87 years), we used a novel method to measure cerebral arterial elasticity (pulse relaxation function [PReFx]) with diffuse optical tomography (pulse-DOT) and investigated its association with WMSAs, age, and cognition. PReFx was associated with WMSAs, with older adults with low PReFx showing the greatest WMSA burden. PReFx in brain regions perfused by the middle cerebral artery showed the largest associations with WMSAs and partially mediated the relationship between age and WMSAs. Finally, WMSAs partially mediated the relationship between PReFx and fluid but not crystallized abilities scores. Taken together, these findings suggest that loss of cerebral arterial elasticity is associated with cerebral white matter lesions and age-related cognitive decline.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.