ArticleVeterinary microbiology2019
Homologous recombination shapes the genetic diversity of African swine fever viruses.
Article in Veterinary microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 46 citations in OpenAlex.
- Live-Attenuated Vaccines Against African Swine Fever: Strategies, Lessons, and Prospects.Biology · 2026Review
- 'PePApipe': A complete bioinformatics analysis pipeline for African Swine Fever Virus genome.PloS one · 2026Article
- Detection of the intergenic region III and multigene family 505 9R and 10R-V variant of African swine fever virus genotype II on pig farms in South Korea.Archives of virology · 2025Article
- Homologous recombination and evolutionary arms race drive the adaptive evolution of African swine fever virus.Veterinary research · 2025Article
- Host-similar fragments in the African swine fever virus genome: distribution, functions, and evolution.Veterinary research · 2025Article
- A synthetic genomics-based African swine fever virus engineering platform.Science advances · 2025Article
- Genetic profile of the whole genome sequence of African swine fever virus from the first outbreak in Malaysian Borneo.Veterinary research communications · 2025Article
- The Potential of Disabled Infectious Single Cycle (DISC) Virus Platforms for Next Generation African Swine Fever Vaccine Development.Transboundary and emerging diseases · 2025Review
- Pathological Characterization of African Swine Fever Viruses With Genetic Deletions Detected in South Korea.Transboundary and emerging diseases · 2025Article
- Article
- Genome Characterization and Phylogenetic Analysis of Scale Drop Disease Virus Isolated from Asian Seabass (Animals : an open access journal from MDPI · 2024Article
- Review
- Nanobodies against African swine fever virus p72 and CD2v proteins as reagents for developing two cELISAs to detect viral antibodies.Virologica Sinica · 2024Article
- Genomic Epidemiology of African Swine Fever Virus Identified in Domestic Pig Farms in South Korea during 2019-2021.Transboundary and emerging diseases · 2024Article
- The Production of Recombinant African Swine Fever Virus Lv17/WB/Rie1 Strains and Their In Vitro and In Vivo Characterizations.Vaccines · 2023Article
- Origin, genomic diversity and evolution of African swine fever virus in East Asia.Virus evolution · 2023Article
- Tracing the Origin of Genotype II African Swine Fever Virus in China by Genomic Epidemiology Analysis.Transboundary and emerging diseases · 2023Article
- Systematic identification and characterization of repeat sequences in African swine fever virus genomes.Veterinary research · 2022Article
- A Review of Pseudorabies Virus Variants: Genomics, Vaccination, Transmission, and Zoonotic Potential.Viruses · 2022Review
- Genome Plasticity of African Swine Fever Virus: Implications for Diagnostics and Live-Attenuated Vaccines.Pathogens (Basel, Switzerland) · 2022Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The African swine fever virus (ASFV) has severely influenced the swine industry of the world. Currently, there is no effective vaccine or drugs against the ASFV. How to effectively control the virus is challenging. In this study, we have analyzed all the publicly available ASFV genomes and demonstrated that there was a large genetic diversity of ASFV genomes. Interestingly, the genetic diversity was mainly caused by extensive genomic insertions and/or deletions (indels) instead of the point mutations. Further analyses showed that the indels may be attributed much to the homologous recombination, as supported by significant associations between the occurrence of extensive recombination events and the indels in the ASFV genomes. Besides, the homologous recombination also led to changes of gene content of ASFVs. Finally, repeated elements of dozens of nucleotides in length were observed to widely distribute and cluster in the adjacent positions of ASFV genomes, which may facilitate the occurrence of homologous recombination. This work highlighted the importance of homologous recombination in shaping the genetic diversity of the ASFVs, and could help understand the evolution of the virus.
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