Evidence map›Paper›PMID 31500626›Full record

Observational studyPediatric rheumatology online journal2019

Complement lectin pathway protein levels reflect disease activity in juvenile idiopathic arthritis: a longitudinal study of the Nordic JIA cohort.

Mia Glerup, Steffen Thiel, Veronika Rypdal, Ellen Dalen Arnstad, Maria Ekelund, Suvi Peltoniemi, Kristiina Aalto, Marite Rygg, Susan Nielsen, Anders Fasth and 4 more

Open access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric rheumatology online journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  3. Article
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  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Mia GlerupDepartment of Pediatrics, Aarhus University Hospital, Palle Juul-Jensens Blvd. 99, 8200, Aarhus N, Denmark. miagleru@rm.dk.ORCID http://orcid.org/0000-0002-9128-9908
Steffen ThielDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Veronika RypdalDepartment of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Ellen Dalen ArnstadDepartment of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Maria EkelundDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Suvi PeltoniemiNew Children's Hospital, Pediatric Research Center, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
Kristiina AaltoNew Children's Hospital, Pediatric Research Center, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
Marite RyggDepartment of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Susan NielsenDepartment of Pediatrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Anders FasthDepartment of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Lillemor BerntsonDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Ellen NordalDepartment of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
Troels HerlinDepartment of Pediatrics, Aarhus University Hospital, Palle Juul-Jensens Blvd. 99, 8200, Aarhus N, Denmark.
Nordic Study Group of Pediatric Rheumatology (NoSPeR)
Uppsala University · SEUniversity Hospital of North Norway · NOAarhus University Hospital · DKUniversity of Helsinki · FIAarhus University · DKCopenhagen University Hospital · DKNorwegian University of Science and Technology · NO

Funding

Gigtforeningen R125-A3302-B842
6 · The paper itself

Abstract

backgroundTo determine the serum levels of the lectin pathway proteins early in the disease course and 17 years after disease onset and to correlate the protein levels to markers of disease activity in participants from a population-based Nordic juvenile idiopathic arthritis (JIA) cohort. Additionally, to assess the predictive value of lectin pathway proteins with respect to remission status.

methodsA population-based cohort study of consecutive cases of JIA with a disease onset from 1997 to 2000 from defined geographical areas of Finland, Sweden, Norway and Denmark with 17 years of follow-up was performed. Clinical characteristics were registered and H-ficolin, M-ficolin, MASP-1, MASP-3, MBL and CL-K1 levels in serum were analyzed.

resultsIn total, 293 patients with JIA were included (mean age 23.7 ± 4.4 years; mean follow-up 17.2 ± 1.7 years). Concentrations of the lectin protein levels in serum were higher at baseline compared to the levels 17 years after disease onset (p ≤ 0.006, n = 164). At baseline, the highest level of M-ficolin was observed in systemic JIA. Further, high M-ficolin levels at baseline and at 17-year follow-up were correlated to high levels of ESR. In contrast, high MASP-1 and MASP-3 tended to correlate to low ESR. CL-K1 showed a negative correlation to JADAS71 at baseline. None of the protein levels had prognostic abilities for remission status 17 years after disease onset.

conclusionWe hypothesize that increased serum M-ficolin levels are associated with higher disease activity in JIA and further, the results indicate that MASP-1, MASP-3 and CL-K1 are markers of inflammation.

Indexed as

AdolescentArthritis, JuvenileBiomarkersChildCollectinsFemaleFicolinsHumansLectinsLongitudinal StudiesMaleMannose-Binding LectinMannose-Binding Protein-Associated Serine ProteasesProspective StudiesScandinavian and Nordic CountriesYoung AdultBiomarkersCOLEC10 protein, humanCollectinsFCN3 protein, humanFicolinsLectinsMannose-Binding LectinMannose-Binding Protein-Associated Serine ProteasesMASP1 protein, humanDisease activityJIALectin pathway proteins

Identifiers

PMID31500626
PMCPMC6734250
OpenAlexW2972438682

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.