Evidence map›Paper›PMID 31500513›Full record

ArticleCell cycle (Georgetown, Tex.)2019

PIR promotes tumorigenesis of breast cancer by upregulating cell cycle activator E2F1.

Muhammad Suleman, Ai Chen, Huanhuan Ma, Shixiong Wen, Wentao Zhao, Donghai Lin, Guode Wu, Qinxi Li

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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  13. [Advancement of E2F1 in Common Tumors].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Muhammad SulemanState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University , Xiamen , Fujian , China.
Ai ChenState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University , Xiamen , Fujian , China.
Huanhuan MaState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University , Xiamen , Fujian , China.ORCID https://orcid.org/0000-0001-8029-6814
Shixiong WenState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University , Xiamen , Fujian , China.
Wentao ZhaoState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University , Xiamen , Fujian , China.
Donghai LinDepartment of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen , Fujian , China.
Guode WuDepartment of Neurology, Lanzhou University Second Hospital , Lanzhou , China.
Qinxi LiState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University , Xiamen , Fujian , China.
Xiamen University · CNLanzhou University Second Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pirin (PIR) protein belongs to the superfamily of cupin and is highly conserved between eukaryotic and prokaryotic organisms. It has been reported that PIR is upregulated in various tumors and involved in tumorigenesis. However, its biological functions particularly in promoting tumorigenesis are, to date, poorly characterized. Here we report that knockdown of

Indexed as

AnimalsBreast NeoplasmsCell Line, TumorCell ProliferationCell Transformation, NeoplasticDioxygenasesE2F1 Transcription FactorFemaleG1 Phase Cell Cycle CheckpointsGene Expression Regulation, NeoplasticHEK293 CellsHumansMCF-7 CellsMiceMice, Inbred BALB CMice, NudeDioxygenasesE2F1 protein, humanE2F1 Transcription FactorPIR protein, humantumorigenesis

Identifiers

PMID31500513
PMCPMC6791709
OpenAlexW2972798209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.