Evidence map›Paper›PMID 31500399›Full record

ArticleInternational journal of molecular sciences2019

Apoptotic Effects of Drug Targeting Conjugates Containing Different GnRH Analogs on Colon Carcinoma Cells.

Eszter Lajkó, Rózsa Hegedüs, Gábor Mező, László Kőhidai

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Eszter LajkóDepartment Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, 1089 Budapest, Hungary. lajesz@gmail.com.
Rózsa HegedüsResearch Group of Peptide Chemistry, Hungarian Academy of Sciences, Eötvös Loránd University, Pázmány Péter sétány 1/A, 1117 Budapest, Hungary. rozsa.hegedus@gmail.com.
Gábor MezőResearch Group of Peptide Chemistry, Hungarian Academy of Sciences, Eötvös Loránd University, Pázmány Péter sétány 1/A, 1117 Budapest, Hungary. gmezo@caesar.elte.hu.
László KőhidaiDepartment Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, 1089 Budapest, Hungary. kohlasz2@gmail.com.
Semmelweis University · HUEötvös Loránd University · HUHungarian Academy of Sciences · HU

Funding

Nemzeti versenyképességi és kiválósági program NVKP_16-1-2016-0036
6 · The paper itself

Abstract

The wide range of cellular target reactions (e.g., antitumor) of gonadotropin-releasing hormone (GnRH) variants provides the possibility to develop multifunctional GnRH conjugates. The aim of our work was to compare the cytotoxic/apoptotic activity of different GnRH-based, daunorubicin (Dau)-linked conjugates with or without butyrated Lys in position 4 (

Indexed as

AnimalsAntineoplastic Agents, HormonalApoptosisCell Line, TumorCell ProliferationColonic NeoplasmsComputational BiologyDaunorubicinDose-Response Relationship, DrugGene Expression ProfilingGonadotropin-Releasing HormoneHumansTranscriptomeAntineoplastic Agents, HormonalDaunorubicinGonadotropin-Releasing Hormoneapoptosisbutyrateconjugationdaunorubicindrug-targeting conjugatesFASLgonadotropin-releasing hormoneimpedimetryTNFTP53

Identifiers

PMID31500399
PMCPMC6769516
OpenAlexW2971626815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.