Evidence map›Paper›PMID 31500350›Full record

ReviewInternational journal of molecular sciences2019

Advances in Molecular Biology and Targeted Therapy of Mantle Cell Lymphoma.

Pavel Klener

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. High-Risk Mantle Cell Lymphoma in the Era of Novel Agents.Current hematologic malignancy reports · 2021
    Review
  12. Review
  13. Article
  14. Article
  15. ConcurrentCancers · 2020
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Pavel KlenerFirst Dept. of Medicine-Hematology, General University Hospital in Prague, 128 08 Prague, Czech Republic. pavel.klener2@lf1.cuni.cz.ORCID 0000-0001-7786-9378
Charles University · CZ

Funding

Ministry of Health of the Czech Republic AZV 17-28980A
6 · The paper itself

Abstract

Mantle cell lymphoma (MCL) is a heterogeneous malignancy with a broad spectrum of clinical behavior from indolent to highly aggressive cases. Despite the fact that MCL remains in most cases incurable by currently applied immunochemotherapy, our increasing knowledge on the biology of MCL in the last two decades has led to the design, testing, and approval of several innovative agents that dramatically changed the treatment landscape for MCL patients. Most importantly, the implementation of new drugs and novel treatment algorithms into clinical practice has successfully translated into improved outcomes of MCL patients not only in the clinical trials, but also in real life. This review focuses on recent advances in our understanding of the pathogenesis of MCL, and provides a brief survey of currently used treatment options with special focus on mode of action of selected innovative anti-lymphoma molecules. Finally, it outlines future perspectives of patient management with progressive shift from generally applied immunotherapy toward risk-stratified, patient-tailored protocols that would implement innovative agents and/or procedures with the ultimate goal to eradicate the lymphoma and cure the patient.

Indexed as

Molecular Targeted TherapyAnimalsAntineoplastic AgentsBiomarkers, TumorCell CycleClonal EvolutionCombined Modality TherapyDisease SusceptibilityDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticGenetic VariationHumansLymphoma, Mantle-CellPrognosisReceptors, Antigen, B-CellRecurrenceAntineoplastic AgentsBiomarkers, TumorReceptors, Antigen, B-CellB-cell receptor signalingcell cyclemantle cell lymphoma

Identifiers

PMID31500350
PMCPMC6770169
OpenAlexW2971785858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.