Evidence map›Paper›PMID 31500145›Full record

ArticleNutrients2019

Acute/Subacute and Sub-Chronic Oral Toxicity of a Hidroxytyrosol-Rich Virgin Olive Oil Extract.

Avilene Rodríguez-Lara, María Dolores Mesa, Jerónimo Aragón-Vela, Rafael A Casuso, Cristina Casals Vázquez, Jesús M Zúñiga, Jesús R Huertas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. The effect of diazinon on blood glucose homeostasis: a systematic and meta-analysis study.Environmental science and pollution research international · 2021
    Pooled it
  2. The Beneficial Effect ofAnalytical cellular pathology (Amsterdam) · 2025
    Article
  3. Article
  4. Providing a Population Based Registry Model of Drug Poisoning in Iran.Iranian journal of pharmaceutical research : IJPR · 2022
    Article
  5. Article
  6. Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Avilene Rodríguez-LaraDepartment of Physiology, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, University of Granada, Parque Tecnológico de la Salud, Avenida del Conocimiento s/n, 18016 Granada, Spain.
María Dolores MesaDepartment of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, University of Granada, Parque Tecnológico de la Salud, Avenida del Conocimiento s/n, 18016 Granada, Spain.
Jerónimo Aragón-VelaDepartment of Physiology, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, University of Granada, Parque Tecnológico de la Salud, Avenida del Conocimiento s/n, 18016 Granada, Spain.
Rafael A CasusoDepartment of Physiology, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, University of Granada, Parque Tecnológico de la Salud, Avenida del Conocimiento s/n, 18016 Granada, Spain.
Cristina Casals VázquezDepartment of Physiology, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, University of Granada, Parque Tecnológico de la Salud, Avenida del Conocimiento s/n, 18016 Granada, Spain.
Jesús M ZúñigaCentro de Instrumentación Científica, University of Granada, 18016 Granada, Spain.
Jesús R HuertasDepartment of Physiology, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, University of Granada, Parque Tecnológico de la Salud, Avenida del Conocimiento s/n, 18016 Granada, Spain. jhuertas@ugr.es.
Universidad de Granada · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to determine the acute (one single dose), subacute (14 days), and sub-chronic (90 days) toxicity of an aqueous virgin olive oil (VOO) extract rich in hydroxytyrosol in rats. For acute/subacute toxicity, rats were divided into three groups. The control group received distilled water (

Indexed as

Toxicity Tests, AcuteToxicity Tests, SubacuteToxicity Tests, SubchronicAnimalsFemaleMaleNo-Observed-Adverse-Effect LevelOlive OilPhenylethyl AlcoholRats, WistarRisk AssessmentTime Factors3,4-dihydroxyphenylethanolOlive OilPhenylethyl Alcoholacute toxicityhydroxytyrosolsafetysubacute toxicitysubchronic toxicityvirgin olive oil

Identifiers

PMID31500145
PMCPMC6770357
OpenAlexW2971577857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.