Evidence map›Paper›PMID 31500101›Full record

ArticleMetabolites2019

Multiplatform Urinary Metabolomics Profiling to Discriminate Cachectic from Non-Cachectic Colorectal Cancer Patients: Pilot Results from the ColoCare Study.

Jennifer Ose, Biljana Gigic, Tengda Lin, David B Liesenfeld, Jürgen Böhm, Johanna Nattenmüller, Dominique Scherer, Lin Zielske, Petra Schrotz-King, Nina Habermann and 13 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Metabolites, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02328677 recruitingnot on this map

ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis

TypeobservationalSponsorUniversity of UtahRan2007 to 2030Enrolled5,000ConditionsColorectal Cancer
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Trajectories and risk factors of fatigue following colorectal cancer diagnosis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2023
    Article
  5. Article
  6. Review
  7. Urine NMR Metabolomics for Precision Oncology in Colorectal Cancer.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Review
  10. Article
  11. Metabolic Biomarkers for the Early Detection of Cancer Cachexia.Frontiers in cell and developmental biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 10 institutions in 2 countries.

Jennifer OseHuntsman Cancer Institute, Salt Lake City, UT 84112, USA. jennifer.ose@hci.utah.edu.ORCID 0000-0002-2030-9676
Biljana GigicDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, 69117 Heidelberg, Germany. biljana.gigic@med.uni-heidelberg.de.
Tengda LinHuntsman Cancer Institute, Salt Lake City, UT 84112, USA. Tengda.lin@hci.utah.edu.
David B LiesenfeldDivision of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), 69117 Heidelberg, Germany. davidliesenfeld@gmx.de.
Jürgen BöhmHuntsman Cancer Institute, Salt Lake City, UT 84112, USA. boehm.juergen@outlook.com.
Johanna NattenmüllerDiagnostic and Interventional Radiology, University of Heidelberg, 69117 Heidelberg, Germany. johannawelzel@gmail.com.
Dominique SchererInstitute of Medical Biometry and Informatics, University of Heidelberg, 69117 Heidelberg, Germany. Dominique.Scherer@uni-heidelberg.de.ORCID 0000-0003-4430-296X
Lin ZielskeDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, 69117 Heidelberg, Germany. l.zielske@dkfz-heidelberg.de.
Petra Schrotz-KingDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, 69117 Heidelberg, Germany. petra.schrotz-king@nct-heidelberg.de.
Nina HabermannEuropean Molecular Biology Laboratory (EMBL), Genome Biology, 69117 Heidelberg, Germany. nina.habermann@embl.de.
Heather M Ochs-BalcomHuntsman Cancer Institute, Salt Lake City, UT 84112, USA. hmochs2@buffalo.edu.
Anita R PeoplesHuntsman Cancer Institute, Salt Lake City, UT 84112, USA. anita.peoples@hci.utah.edu.
Sheetal HardikarHuntsman Cancer Institute, Salt Lake City, UT 84112, USA. sheetal.hardikar@hci.utah.edu.
Christopher I LiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. cili@fredhutch.org.
David ShibataDepartment of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA. dshibata@uthsc.edu.
Jane FigueiredoSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Jane.Figueiredo@cshs.org.
Adetunji T ToriolaDepartment of Surgery, Washington University School of Medicine and Siteman Cancer Center, St. Louis, MO 63110, USA. toriolaa@wudosis.wustl.edu.
Erin M SiegelCancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Erin.Siegel@moffitt.org.
Stephanie SchmitCancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Stephanie.Schmit@moffitt.org.
Martin SchneiderDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, 69117 Heidelberg, Germany. martin.schneider@med.uni-heidelberg.de.
Alexis UlrichDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, 69117 Heidelberg, Germany. aulrich@lukasneuss.de.
Hans-Ulrich KauczorDiagnostic and Interventional Radiology, University of Heidelberg, 69117 Heidelberg, Germany. Hans-Ulrich.Kauczor@med.uni-heidelberg.de.
Cornelia M UlrichHuntsman Cancer Institute, Salt Lake City, UT 84112, USA. neli.ulrich@hci.utah.edu.
Heidelberg University · DEUniversity of Utah · USHuntsman Cancer Institute · USMoffitt Cancer Center · USCedars-Sinai Medical Center · USEuropean Molecular Biology Laboratory · DEFred Hutch Cancer Center · USGerman Cancer Research Center · DEUniversity of Tennessee Health Science Center · USWashington University in St. Louis · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KATHARINE S ULLMAN · 1986 to 2026
$72.6M
Transdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare StudyU01CA206110 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jane C. Figueiredo, Christopher I Li · 2016 to 2026
$18.6M
Discovery and verification of novel biomarkers of colorectal cancer recurrenceR01CA189184 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LI, CHRISTOPHER I, ULRICH, CORNELIA M · 2015 to 2020
$5.6M
Metabolomic Strategies for Discovery and Validation of Biomarkers of Colorectal Cancer RecurrenceR01CA207371 · NCI · UNIVERSITY OF UTAH · PI LI, CHRISTOPHER I, ULRICH, CORNELIA M · 2017 to 2022
$3.9M
Diabetes, Medications and the Cost-Effectiveness of Screening for Colorectal NeoplasiaK07CA222060 · NCI · UNIVERSITY OF UTAH · PI HARDIKAR, SHEETAL · 2018 to 2022
$791k
ERA-NET on Translational Cancer Research (TRANSCAN) 01KT1503Lackas Foundation NANCI NIH HHS K07 CA222060NCI NIH HHS P30 CA042014NCI NIH HHS R01 CA189184NCI NIH HHS R01 CA207371NCI NIH HHS U01 CA206110Stiftung Lebensblicke NA
6 · The paper itself

Abstract

Cachexia is a multifactorial syndrome that is characterized by loss of skeletal muscle mass in cancer patients. The biological pathways involved remain poorly characterized. Here, we compare urinary metabolic profiles in newly diagnosed colorectal cancer patients (stage I-IV) from the ColoCare Study in Heidelberg, Germany. Patients were classified as cachectic (

Indexed as

cancer cachexiacolorectal cancermetabolomicsserial samplesurinary profiles

Identifiers

PMID31500101
PMCPMC6780796
OpenAlexW2972078347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.