Evidence map›Paper›PMID 31499515›Full record

ArticlePediatric research2020

Reduced brain mammillary body volumes and memory deficits in adolescents who have undergone the Fontan procedure.

Cristina Cabrera-Mino, Bhaswati Roy, Mary A Woo, Sadhana Singh, Stefanie Moye, Nancy J Halnon, Alan B Lewis, Rajesh Kumar, Nancy A Pike

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06326996 (Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting - A Randomized Clinical Trial.), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06326996 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Thiamine Intervention and Cognition in Older Adults Undergoing Coronary Artery Bypass Grafting - A Randomized Clinical Trial.

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2026Enrolled52ConditionsCoronary Heart Disease, Coronary Artery Bypass GraftingArmsThiamine, Placebo
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Cell-Type Specific Circuits in the Mammillary Body for Place and Object Recognition Memory.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Observational
  9. Time to put the mammillothalamic pathway into context.Neuroscience and biobehavioral reviews · 2021
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Cristina Cabrera-MinoUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Bhaswati RoyUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Mary A WooUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Sadhana SinghDepartment of Anesthesiology, University of California Los Angeles, Los Angeles, CA, USA.
Stefanie MoyeUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Nancy J HalnonDivision of Pediatric Cardiology, University of California Los Angeles, Los Angeles, CA, USA.
Alan B LewisDivision of Pediatric Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Rajesh KumarDepartment of Anesthesiology, University of California Los Angeles, Los Angeles, CA, USA.
Nancy A PikeUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA. npike@sonnet.ucla.edu.
University of California, Los Angeles · USChildren's Hospital of Los Angeles · US

Funding

Cerebral Artery Integrity Linked to Brain Injury and Cognition in Congenital Heart DiseaseR01NR016463 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, PIKE, NANCY ANN · 2016 to 2019
$2.0M
Memory and Brain Structure in Adolescents with Single Ventricle Heart DiseaseR01NR013930 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIKE, NANCY ANN · 2013 to 2016
$1.4M
NINR NIH HHS R01 NR013930NINR NIH HHS R01 NR016463
6 · The paper itself

Abstract

backgroundAdolescents with single ventricle heart disease (SVHD) who have undergone the Fontan procedure show cognitive/memory deficits. Mammillary bodies are key brain sites that regulate memory; however, their integrity in SVHD is unclear. We evaluated mammillary body (MB) volumes and their associations with cognitive/memory scores in SVHD and controls.

methodsBrain MRI data were collected from 63 adolescents (25 SVHD; 38 controls) using a 3.0-Tesla MRI scanner. Cognition and memory were assessed using Montreal Cognitive Assessment (MoCA) and Wide Range Assessment of Memory and Learning 2. MB volumes were calculated and compared between groups (ANCOVA, covariates: age, sex, and total brain volume [TBV]). Partial correlations and linear regression were performed to examine associations between volumes and cognitive scores (covariates: age, sex, and TBV).

resultsSVHD group showed significantly lower MoCA and WRAML2 scores over controls. MB volumes were significantly reduced in SVHD over controls. After controlling for age, sex, and TBV, MB volumes correlated with MoCA and delayed memory recall scores in SVHD and controls.

conclusionAdolescents with SVHD show reduced MB volumes associated with cognitive/memory deficits. Potential mechanisms of volume losses may include developmental and/or hypoxic/ischemic-induced processes. Providers should screen for cognitive deficits and explore possible interventions to improve memory.

Indexed as

CognitionMagnetic Resonance ImagingMemoryAdolescentCase-Control StudiesCognitive DysfunctionFemaleFontan ProcedureHumansMaleMammillary BodiesMemory DisordersNeuropsychological TestsPredictive Value of TestsTreatment OutcomeUniventricular Heart

Identifiers

PMID31499515
PMCPMC6962527
OpenAlexW2972287814

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.