Evidence map›Paper›PMID 31499481›Full record

ArticleArchives of medical research2019

Striatal Glutathione in First-episode Psychosis Patients Measured In Vivo with Proton Magnetic Resonance Spectroscopy.

Francisco Reyes-Madrigal, Pablo León-Ortiz, Xiangling Mao, Ricardo Mora-Durán, Dikoma C Shungu, Camilo de la Fuente-Sandoval

Open access · greenAbstract read
In one paragraph

Article in Archives of medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Schizophrenia and Glutathione: A Challenging Story.Journal of personalized medicine · 2023
    Review
  4. Article
  5. Article
  6. In Vivo Brain GSH: MRS Methods and Clinical Applications.Antioxidants (Basel, Switzerland) · 2021
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Francisco Reyes-MadrigalLaboratorio de Psiquiatría Experimental, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
Pablo León-OrtizLaboratorio de Psiquiatría Experimental, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México; Subdirección de Enseñanza, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.
Xiangling MaoDepartment of Radiology, Weill Cornell Medical College, New York City, NY, USA.
Ricardo Mora-DuránDepartamento de Urgencias, Hospital Fray Bernardino Álvarez, Ciudad de México, México.
Dikoma C ShunguDepartment of Radiology, Weill Cornell Medical College, New York City, NY, USA.
Camilo de la Fuente-SandovalLaboratorio de Psiquiatría Experimental, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México; Departamento de Neuropsiquiatría, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México. Electronic address: fcamilo@unam.mx.
Instituto Nacional de Neurología y Neurocirugía · MXCornell University · USUniversidad Fray Luca Paccioli · MX

Funding

Biomarkers of Conversion Risk and Treatment Response in Early-Stage SchizophreniaR01MH110270 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI GIRGIS, RAGY RAMSIS, KEGELES, LAWRENCE S · 2017 to 2021
$3.7M
Novel MRS Neurotechnology for Imaging GABA & Glutamate Function in SchizophreniaR01MH075895 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHUNGU, DIKOMA C · 2007 to 2011
$2.3M
3.0T Magnetic Resonance Imaging System for Preclinical, Translational and Clinical ResearchS10OD021782 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2016 to 2016
$2.0M
Specificity and Validity of Oxidative Stress Model of Chronic Fatigue SyndromeR01MH100005 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHUNGU, DIKOMA C · 2013 to 2016
$2.0M
NIH HHS S10 OD021782NIMH NIH HHS R01 MH075895NIMH NIH HHS R01 MH100005NIMH NIH HHS R01 MH110270
6 · The paper itself

Abstract

Deficits of brain glutathione (GSH), the most abundant and primary antioxidant in living tissue, and associated redox imbalance are postulated to be implicated in schizophrenia. This pilot clinical study compared the levels of striatal GSH, measured in vivo with proton magnetic resonance spectroscopy (

Indexed as

AdultFemaleGlutathioneHumansMaleProton Magnetic Resonance SpectroscopyPsychotic DisordersYoung AdultGlutathioneFirst-episodeGlutathioneMagnetic resonance spectroscopyPsychosisSchizophrenia

Identifiers

PMID31499481
PMCPMC10624128
OpenAlexW2972572524

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.