Evidence map›Paper›PMID 31499368›Full record

ArticleThe Journal of surgical research2020

Protective Effect of Phosphatidylserine Blockade in Hemorrhagic Shock.

Caitlin Cohan, Genna Beattie, William Brigode, Louise Yeung, Emily Miraflor, Gregory P Victorino

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Caitlin CohanEast Bay Department of Surgery, University of California San Francisco, Oakland, California. Electronic address: ccohan@alamedahealthsystem.org.
Genna BeattieEast Bay Department of Surgery, University of California San Francisco, Oakland, California.
William BrigodeEast Bay Department of Surgery, University of California San Francisco, Oakland, California.
Louise YeungEast Bay Department of Surgery, University of California San Francisco, Oakland, California.
Emily MiraflorEast Bay Department of Surgery, University of California San Francisco, Oakland, California.
Gregory P VictorinoEast Bay Department of Surgery, University of California San Francisco, Oakland, California.
University of California, San Francisco · US

Funding

Post-Injury Dysregulation of Lipid MetabolismK08GM081361 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VICTORINO, GREGORY P · 2007 to 2011
$594k
NIGMS NIH HHS K08 GM081361
6 · The paper itself

Abstract

backgroundPhosphatidylserine (PS) is a key cell membrane phospholipid normally maintained on the inner cell surface but externalizes to the outer surface in response to cellular stress. We hypothesized that PS exposure mediates organ dysfunction in hemorrhagic shock. Our aims were to evaluate PS blockade on (1) pulmonary, (2) renal, and (3) gut function, as well as (4) serum lysophosphatidic acid (LPA), an inflammatory mediator generated by PS externalization, as a possible mechanism mediating organ dysfunction. MATERIALS AND

methodsRats were either (1) monitored for 130 min (controls, n = 3), (2) hemorrhaged then resuscitated (hemorrhage only group, n = 3), or (3) treated with Diannexin (DA), a PS blocking agent, followed by hemorrhage and resuscitation (DA + hemorrhage group, n = 4). Pulmonary dysfunction was assessed by arterial partial pressure of oxygen, renal dysfunction by serum creatinine, and gut dysfunction by mesenteric endothelial permeability (L

resultsPulmonary: there was no difference in arterial partial pressure of oxygen between groups. Renal: after resuscitation, creatinine levels were lower after PS blockade with DA versus hemorrhage only group (P = 0.01). Gut: L

conclusionsPS blockade with DA decreased renal and gut dysfunction associated with hemorrhagic shock and attenuated the magnitude of LPA generation. Our findings suggest potential for therapeutic targets in the future that could prevent organ dysfunction associated with hemorrhagic shock.

Indexed as

AnimalsAnnexin A5Disease Models, AnimalFemaleHumansInfusions, IntravenousIntestinal MucosaKidneyLungLysophospholipidsOrgan Dysfunction ScoresPhosphatidylserinesRatsResuscitationShock, HemorrhagicTreatment OutcomeAnnexin A5diannexin, humanlysophosphatidic acidLysophospholipidsPhosphatidylserinesDiannexinHemorrhagic shockOrgan dysfunctionPhosphatidylserine

Identifiers

PMID31499368
PMCPMC6900439
OpenAlexW2972169641

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.