Evidence map›Paper›PMID 31499178›Full record

ArticleNeuroImage2019

How to test for phasic modulation of neural and behavioural responses.

Benedikt Zoefel, Matthew H Davis, Giancarlo Valente, Lars Riecke

Registry-linked trialAbstract read
In one paragraph

Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05446350 (Modulating Speech Perception With Current Stimulation), which is not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05446350 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Modulating Speech Perception With Current Stimulation (SPEECHSTIM)

TypeinterventionalSponsorUniversity Hospital, ToulouseRan2022 to 2025Enrolled126ConditionsHealthyArmstranscranial alternating current stimulation (tACS), electroencephalography (EEG), brain imaging (fMRI), electroencephalography (EEG) with neurofeedback
3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Cutaneous Alternating Current Stimulation Can Cause a Phasic Modulation of Speech Perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
  4. The Inattentional Rhythm in Audition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Reliability of Neural Entrainment in the Human Auditory System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Speaking rhythmically can shape hearing.Nature human behaviour · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Benedikt ZoefelMRC Cognition and Brain Sciences Unit, University of Cambridge, UK. Electronic address: benedikt.zoefel@mrc-cbu.cam.ac.uk.
Matthew H DavisMRC Cognition and Brain Sciences Unit, University of Cambridge, UK.
Giancarlo ValenteDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, 6229, EV Maastricht, the Netherlands.
Lars RieckeDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, 6229, EV Maastricht, the Netherlands.

Funding

Medical Research Council MC_UU_00005/5
6 · The paper itself

Abstract

Research on whether perception or other processes depend on the phase of neural oscillations is rapidly gaining popularity. However, it is unknown which methods are optimally suited to evaluate the hypothesized phase effect. Using a simulation approach, we here test the ability of different methods to detect such an effect on dichotomous (e.g., "hit" vs "miss") and continuous (e.g., scalp potentials) response variables. We manipulated parameters that characterise the phase effect or define the experimental approach to test for this effect. For each parameter combination and response variable, we identified an optimal method. We found that methods regressing single-trial responses on circular (sine and cosine) predictors perform best for all of the simulated parameters, regardless of the nature of the response variable (dichotomous or continuous). In sum, our study lays a foundation for optimized experimental designs and analyses in future studies investigating the role of phase for neural and behavioural responses. We provide MATLAB code for the statistical methods tested.

Indexed as

Models, NeurologicalBrainComputer SimulationData Interpretation, StatisticalElectroencephalographyHumansMagnetoencephalographyNeuronsPerceptionTranscranial Direct Current StimulationEEGMEGNeural oscillationsPhaseSimulationstACS

Identifiers

PMID31499178
PMCPMC6773602

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.