Evidence map›Paper›PMID 31499015›Full record

ArticleJournal of dental research2019

Smad7 Regulates Dental Epithelial Proliferation during Tooth Development.

Z Liu, T Chen, D Bai, W Tian, Y Chen

Open access · greenAbstract read
In one paragraph

Article in Journal of dental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. PRX1-positive mesenchymal stem cells drive molar morphogenesis.International journal of oral science · 2024
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. USP34 regulates tooth root morphogenesis by stabilizing NFIC.International journal of oral science · 2021
    Article
  8. Article
  9. Article
  10. Tooth Formation: Are the Hardest Tissues of Human Body Hard to Regenerate?International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Z LiuState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
T ChenState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
D BaiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
W TianState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
Y ChenDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, USA.
Sichuan University · CNState Key Laboratory of Oral DiseasesTulane University · US

Funding

Role of BMP and Wnt signaling in early tooth developmentR01DE024152 · NIDCR · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, YIPING · 2014 to 2018
$1.9M
NIDCR NIH HHS R01 DE024152
6 · The paper itself

Abstract

Tooth morphogenesis involves dynamic changes in shape and size as it proceeds through the bud, cap, and bell stages. This process requires exact regulation of cell proliferation and differentiation. Smad7, a general antagonist against transforming growth factor-β (TGF-β) signaling, is necessary for maintaining homeostasis and proper functionality in many organs. While TGF-β signaling is widely involved in tooth morphogenesis, the precise role of Smad7 in tooth development remains unknown. In this study, we showed that

Indexed as

Cell ProliferationOdontogenesisAnimalsCell Cycle CheckpointsCyclin D1Cyclin-Dependent Kinase Inhibitor p21MesodermMiceMice, KnockoutSignal TransductionSmad7 ProteinTooth GermTransforming Growth Factor betaCcnd1 protein, mouseCdkn1a protein, mouseCyclin D1Cyclin-Dependent Kinase Inhibitor p21Smad7 ProteinSmad7 protein, mouseTransforming Growth Factor betacell proliferationdental epitheliumnegative modulatorTGF-β signalingtooth morphogenesistooth size

Identifiers

PMID31499015
PMCPMC6806130
OpenAlexW2972312703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.