Evidence map›Paper›PMID 31499005›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Mechanoregulation of p38 activity enhances endoplasmic reticulum stress-mediated inflammation by arterial endothelium.

Keith A Bailey, Emily Moreno, Fawaz G Haj, Scott I Simon, Anthony G Passerini

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Embryonic scaling: morphogen gradients, size sensing, and scaler genes.Frontiers in cell and developmental biology · 2026
    Review
  2. Article
  3. The role of interferon regulatory factors in atherosclerosis.Frontiers in cardiovascular medicine · 2025
    Review
  4. Emerging role of IRE1α in vascular diseases.Journal of cell communication and signaling · 2024
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Keith A BaileyDepartment of Biomedical Engineering, University of California-Davis, Davis, California, USA.
Emily MorenoDepartment of Biomedical Engineering, University of California-Davis, Davis, California, USA.
Fawaz G HajDepartment of Nutrition, University of California-Davis, Davis, California, USA.
Scott I SimonDepartment of Biomedical Engineering, University of California-Davis, Davis, California, USA.
Anthony G PasseriniDepartment of Biomedical Engineering, University of California-Davis, Davis, California, USA.
University of California, Davis · US

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1M
Outside-in Mechanotransduced Inflammatory TargetsR01AI047294 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI SIMON, SCOTT IRWIN · 1999 to 2021
$7.0M
Vascular Mimetics to Study Inflammation and AtherosclerosisR01HL082689 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PASSERINI, ANTHONY G., SIMON, SCOTT IRWIN · 2008 to 2016
$3.2M
Role of T cell protein-tyrosine phosphatase in pancreatic islet functionR01DK095359 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAJ, FAWAZ GEORGE · 2014 to 2017
$1.4M
NHLBI NIH HHS R01 HL082689NIAID NIH HHS R01 AI047294NIDDK NIH HHS R01 DK095359NIEHS NIH HHS P42 ES004699
6 · The paper itself

Abstract

Endothelial up-regulation of VCAM-1 at susceptible sites in arteries modulates the recruitment efficiency of inflammatory monocytes that initiates atherosclerotic lesion formation. We reported that hydrodynamic shear stress (SS) mechanoregulates inflammation in human aortic endothelial cells through endoplasmic reticulum (ER) stress

Indexed as

Endoplasmic Reticulum StressArteriesCell NucleusCells, CulturedEndothelium, VascularFemaleHumansInterferon Regulatory Factor-1Malep38 Mitogen-Activated Protein KinasesPhosphorylationTranscription, GeneticVascular Cell Adhesion Molecule-1Interferon Regulatory Factor-1p38 Mitogen-Activated Protein KinasesVascular Cell Adhesion Molecule-1atherosclerosisMAPKmechanotransductionshear stressVCAM-1

Identifiers

PMID31499005
PMCPMC6902662
OpenAlexW2972631858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.