Evidence map›Paper›PMID 31499004›Full record

ArticleBiochemistry2019

Protein Flexibility of the α-Ketoglutarate-Dependent Oxygenase Factor-Inhibiting HIF-1: Implications for Substrate Binding, Catalysis, and Regulation.

Cristina B Martin, Vanessa D Chaplin, Stephen J Eyles, Michael J Knapp

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Cristina B MartinDepartment of Chemistry , University of Massachusetts , Amherst , Massachusetts 01003 , United States.
Vanessa D ChaplinDepartment of Chemistry , University of Massachusetts , Amherst , Massachusetts 01003 , United States.
Stephen J EylesDepartment of Biochemistry and Molecular Biology , University of Massachusetts , Amherst , Massachusetts 01003 , United States.
Michael J KnappDepartment of Chemistry , University of Massachusetts , Amherst , Massachusetts 01003 , United States.ORCID 0000-0002-5643-5121
University of Massachusetts Amherst · US

Funding

Molecular mechanisms of hypoxia sensing by the HIF-hydroxylasesR01GM077413 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI KNAPP, MICHAEL J · 2007 to 2018
$2.2M
NIGMS NIH HHS R01 GM077413
6 · The paper itself

Abstract

Protein dynamics are crucial for the mechanistically ordered enzymes to bind to their substrate in the correct sequence and perform catalysis. Factor-inhibiting HIF-1 (FIH) is a nonheme Fe(II) α-ketoglutarate-dependent oxygenase that is a key hypoxia (low

Indexed as

Binding SitesCatalysisCircular DichroismEscherichia coliHumansHydrogen Deuterium Exchange-Mass SpectrometryHydroxylationHypoxia-Inducible Factor 1, alpha SubunitKetoglutaric AcidsKineticsManganeseMixed Function OxygenasesOxygenPlasmidsProtein BindingProtein DomainsHIF1AN protein, humanHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitKetoglutaric AcidsManganeseMixed Function OxygenasesOxygenRepressor Proteins

Identifiers

PMID31499004
PMCPMC7003530
OpenAlexW2972965187

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.