ArticleHuman brain mapping2020
Neural oscillations and connectivity characterizing the state of tonic experimental pain in humans.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Neurofeedback and attention modulate somatosensory alpha oscillations but not pain perception.PLoS biology · 2025Trial
- Electroencephalography research in neuropathic pain (Review).Molecular medicine reports · 2026Review
- Article
- Predicting Pain: Electroencephalography Signatures of Neural Integration During Experimental Tonic Thermal Pain.European journal of pain (London, England) · 2026Article
- Altered cortical alpha modulations and connectivity in complex regional pain syndrome.The journal of pain · 2026Article
- Transcranial alternating current stimulation (tACS) above individual peak alpha frequency (PAF) does not shift PAF or experimental pain sensitivity: an exploratory study.Frontiers in human neuroscience · 2026Article
- Strategy and Motivation, Rather Than Fatigue, Drive Age-Related Differences in Sustained Attention Performance: Evidence for Decoupled Beta-Band Oscillations.The European journal of neuroscience · 2026Article
- A Novel Investigation of an In-Scanner Alternative to the Cold Pressor Test in Healthy Individuals.Human brain mapping · 2025Article
- Harnessing electroencephalography connectomes for cognitive and clinical neuroscience.Nature biomedical engineering · 2025Review
- Article
- Evoked oscillatory cortical activity during acute pain: Probing brain in pain by transcranial magnetic stimulation combined with electroencephalogram.Human brain mapping · 2024Article
- Local brain oscillations and interregional connectivity differentially serve sensory and expectation effects on pain.Science advances · 2023Article
- Neural processes responsible for the translation of sustained nociceptive inputs into subjective pain experience.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Electroencephalography functional connectivity-A biomarker for painful polyneuropathy.European journal of neurology · 2023Article
- EEG signatures of low back and knee joint pain during movement execution: a short report.Frontiers in rehabilitation sciences · 2023Article
- Early Life Pain Experience Changes Adult Functional Pain Connectivity in the Rat Somatosensory and the Medial Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The temporal and spectral characteristics of expectations and prediction errors in pain and thermoception.eLife · 2021Article
- Sex-differences in network level brain dynamics associated with pain sensitivity and pain interference.Human brain mapping · 2021Article
- Detecting acute pain signals from human EEG.Journal of neuroscience methods · 2021Article
- Neural oscillations and connectivity characterizing the state of tonic experimental pain in humans.Human brain mapping · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Pain is a complex phenomenon that is served by neural oscillations and connectivity involving different brain areas and frequencies. Here, we aimed to systematically and comprehensively assess the pattern of neural oscillations and connectivity characterizing the state of tonic experimental pain in humans. To this end, we applied 10-min heat pain stimuli consecutively to the right and left hand of 39 healthy participants and recorded electroencephalography. We systematically analyzed global and local measures of oscillatory brain activity, connectivity, and graph theory-based network measures during tonic pain and compared them to a nonpainful control condition. Local measures showed suppressions of oscillatory activity at alpha frequencies together with stronger connectivity at alpha and beta frequencies in sensorimotor areas during tonic pain. Furthermore, sensorimotor areas contralateral to stimulation showed significantly increased connectivity to a common area in the medial prefrontal cortex at alpha frequencies. Together, these observations indicate that the state of tonic experimental pain is associated with a sensorimotor-prefrontal network connected at alpha frequencies. These findings represent a step further toward understanding the brain mechanisms underlying long-lasting pain states in health and disease.
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