Observational studyThe Journal of clinical endocrinology and metabolism2019
Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries.
Observational study in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05124457 (A Phase 2 Open Label Randomized Controlled Trial Determir Vs Neutral Protamine Hagedorn), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase 2 Open Label Randomized Controlled Trial Determir Vs Neutral Protamine Hagedorn (NPH) In Pregnant Women: DETERMINE Study
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The Gestational Effects of Maternal Appetite Axis Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Mediators of lifestyle intervention effects on neonatal adiposity: are we missing a piece of the puzzle?Pediatric research · 2022Trial
- Early-life proteomic and microbiome features signal obesity risk across 26 years of follow-up.mSystems · 2026Article
- Associations between maternal prepregnancy body mass index and maternal and cord blood metabolome.Journal of the Endocrine Society · 2026Article
- Maternal BCAA overnutrition programs persistent dysglycemia in lean adult offspring.Molecular metabolism · 2026Article
- Cord serum metabolic signatures associated with neonatal anthropometry and neurodevelopment through age two in twins.iScience · 2026Article
- An encyclopedia of the cord blood metabolome reveals maternal-fetal interactions and disease risk.Cell reports. Medicine · 2026Article
- Comparative metabolomic profiling reveals distinct metabolic signatures in amniotic fluid and umbilical cord blood between advanced and young maternal age pregnancies.BMC pregnancy and childbirth · 2025Article
- Alterations in newborn metabolite patterns with preterm birth and diabetes in pregnancy.Pediatric research · 2025Article
- Association between the third trimester maternal serum metabolome and child growth and development through the first year of life.Scientific reports · 2024Article
- Correlation between newborn weight and serum BCAAs in pregnant women with diabetes.Nutrition & diabetes · 2024Article
- Can the triglyceride-glucose index predict insulin resistance in LGA newborns?Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Associations of maternal plasma and umbilical cord plasma metabolomics profiles with birth anthropometric measures.Pediatric research · 2023Article
- Maternal and Cord Blood Serum Metabolite Associations with Childhood Adiposity and Body Composition Outcomes.Metabolites · 2023Article
- Cord Blood Plasma Metabolome-wide Associations With Height From Birth to Adolescence.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Impact of Maternal Weight Gain on the Newborn Metabolome.Metabolites · 2023Article
- Novel Metabolic Subtypes in Pregnant Women and Risk of Early Childhood Obesity in Offspring.JAMA network open · 2023Article
- Associations between cord blood metabolic factors and early-childhood growth and overweight and obesity.Frontiers in endocrinology · 2023Article
- Gestational Diabetes Mellitus and Antenatal Corticosteroid Therapy-A Narrative Review of Fetal and Neonatal Outcomes.Journal of clinical medicine · 2022Review
- Associations of Cord Blood Lipids with Childhood Adiposity at the Age of Three Years: A Prospective Birth Cohort Study.Metabolites · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
contextNewborn adiposity is associated with childhood obesity. Cord blood metabolomics is one approach that can be used to understand early-life contributors to adiposity and insulin resistance.
objectiveTo determine the association of cord blood metabolites with newborn adiposity and hyperinsulinemia in a multiethnic cohort of newborns.
designCross-sectional, observational study.
settingHyperglycemia and Adverse Pregnancy Outcome study.
participantsOne thousand six hundred multiethnic mother-newborn pairs.
main outcome measureCord blood C-peptide, birthweight, and newborn sum of skinfolds.
resultsMeta-analyses across four ancestry groups (Afro-Caribbean, Northern European, Thai, and Mexican American) demonstrated significant associations of cord blood metabolites with cord blood C-peptide, birthweight, and newborn sum of skinfolds. Several metabolites, including branched-chain amino acids (BCAAs), medium- and long-chain acylcarnitines, nonesterified fatty acids, and triglycerides were negatively associated with cord C-peptide but positively associated with birthweight and/or sum of skinfolds. 1,5-Anhydroglucitol, an inverse marker of recent maternal glycemia, was significantly inversely associated with birthweight and sum of skinfolds. Network analyses revealed groups of interrelated amino acid, acylcarnitine, and fatty acid metabolites associated with all three newborn outcomes.
conclusionsCord blood metabolites are associated with newborn size and cord blood C-peptide levels after adjustment for maternal body mass index and glucose during pregnancy. Negative associations of metabolites with C-peptide at birth were observed. 1,5-Anhydroglucitol appears to be a marker of adiposity in newborns. BCAAs were individually associated with birthweight and demonstrated possible associations with newborn adiposity in network analyses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.