SynthesisPloS one2019
Expression of genes in the skeletal muscle of individuals with cachexia/sarcopenia: A systematic review.
Synthesis in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Changes in Protein Metabolism and Early Development of Sarcopenia in Mice With Cholestatic Liver Disease.Journal of cachexia, sarcopenia and muscle · 2025Article
- An in vitro model to study molecular pathogenesis of sarcopenia established by a SASP-dependent human myotube culture.PloS one · 2025Article
- Oral Administration of Nacre Extract from Pearl Oyster Shells Has Anti-Aging Effects on Skin and Muscle, and Extends the Lifespan in SAMP8 Mice.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Sex-specific alteration in human muscle transcriptome with age.GeroScience · 2023Article
- Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting.International journal of molecular sciences · 2023Review
- Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle.Experimental gerontology · 2022Article
- Aberrant mitochondrial homeostasis at the crossroad of musculoskeletal ageing and non-small cell lung cancer.PloS one · 2022Article
- Skeletal muscle wasting after a severe burn is a consequence of cachexia and sarcopenia.JPEN. Journal of parenteral and enteral nutrition · 2021Review
- The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function.eLife · 2021Article
- Zebrafish models of sarcopenia.Disease models & mechanisms · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCachexia occurs in individuals affected by chronic diseases in which systemic inflammation leads to fatigue, debilitation, decreased physical activity and sarcopenia. The pathogenesis of cachexia-associated sarcopenia is not fully understood.
objectivesThe aim of this systematic review is to summarize the current evidence on genes expressed in the skeletal muscles of humans with chronic disease-associated cachexia and/or sarcopenia (cases) compared to controls and to assess the strength of such evidence.
methodsWe searched PubMed, EMBASE and CINAHL using three concepts: cachexia/sarcopenia and associated symptoms, gene expression, and skeletal muscle.
resultsEighteen genes were studied in at least three research articles, for a total of 27 articles analyzed in this review. Participants were approximately 60 years of age and majority male; sample size was highly variable. Use of comparison groups, matching criteria, muscle biopsy location, and definitions of cachexia and sarcopenia were not homogenous. None of the studies fulfilled all four criteria used to assess the quality of molecular analysis, with only one study powered on the outcome of gene expression. FOXO1 was the only gene significantly increased in cases versus healthy controls. No study found a significant decrease in expression of genes involved in autophagy, apoptosis or inflammation in cases versus controls. Inconsistent or non-significant findings were reported for genes involved in protein degradation, muscle differentiation/growth, insulin/insulin growth factor-1 or mitochondrial transcription.
conclusionCurrently available evidence on gene expression in the skeletal muscles of humans with chronic disease-associated cachexia and/or sarcopenia is not powered appropriately and is not homogenous; therefore, it is difficult to compare results across studies and diseases.
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