ArticlePloS one2019
Isolation of five Enterobacteriaceae species harbouring blaNDM-1 and mcr-1 plasmids from a single paediatric patient.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Antibiotic resistance in Pakistan: a systematic review of past decade.BMC infectious diseases · 2021Pooled it
- New Delhi Metallo-β-Lactamase Plasmidomes of Intensive Care Unit Clinical and Environmental Enterobacterales Isolates.Open forum infectious diseases · 2026Article
- Genomic epidemiology of carbapenemase-producingMicrobiology spectrum · 2026Article
- National genomic surveillance reveals global plasmid and chromosomal dissemination routes of blanpj antimicrobials and resistance · 2026Article
- Environmental reservoirs of carbapenem-resistant organisms in the intensive care unit: a multicenter longitudinal study in two middle-income country hospitals.Antimicrobial resistance and infection control · 2026Article
- Plasmid diversity in Klebsiella pneumoniae ST307 co-producing KPC plus NDM recovered during the COVID-19 pandemic.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2025Article
- Urban wastewater overflows as hotspots for dissemination of bacteria producing extended-spectrum β-lactamases and carbapenemases in the Suquía River, Argentina.Frontiers in microbiology · 2025Article
- Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2024Review
- Insights intoInternational journal of molecular sciences · 2024Article
- Emergence of NDM-producing Enterobacterales infections in companion animals from Argentina.BMC veterinary research · 2024Article
- New insights on mcr-1-harboring plasmids from human clinical Escherichia coli isolates.PloS one · 2024Article
- Co-integrate Col3mMicrobiology spectrum · 2023Article
- Emergence of Hyper-Epidemic Clones of Enterobacterales Clinical Isolates Co-Producing KPC and Metallo-Beta-Lactamases during the COVID-19 Pandemic.Pathogens (Basel, Switzerland) · 2023Article
- Application of Artificial Intelligence in Combating High Antimicrobial Resistance Rates.Antibiotics (Basel, Switzerland) · 2022Review
- Dissemination of carbapenemase-producing Enterobacterales in the community of Rawalpindi, Pakistan.PloS one · 2022Article
- Carbapenemase-Producing Extraintestinal PathogenicFrontiers in microbiology · 2022Article
- Molecular Mechanisms Influencing Bacterial Conjugation in the Intestinal Microbiota.Frontiers in microbiology · 2021Review
- Genomic Analysis of two NDM-1 Providencia stuartii Strains Recovered from a Single Patient.Current microbiology · 2020Article
- Whole Genome Sequencing of PeruvianOpen forum infectious diseases · 2020Article
- Discovery of a Novel Natural Allosteric Inhibitor That Targets NDM-1 AgainstFrontiers in pharmacology · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Argentina, NDM metallo-β-lactamase was first reported in 2013. By now, it has disseminated throughout the country in diverse Gram negative bacteria. Here, we report the case of a paediatric patient that underwent a 1-year hospitalisation due to erythrodermic psoriasis in 2014 and received multiple antimicrobial treatments. During his stay, five isolates were obtained from rectal swabs (rs) or blood culture (bc) suspicious of carbapenemase production: a K. quasipneumoniae subsp. quasipneumoniae (rs), Citrobacter freundii (rs), Escherichia coli (bc), Enterobacter cloacae (rs), and a Serratia marcescens (bc). The isolates were studied with broth microdilution, biparental conjugation and plasmid and whole genome sequencing (Illumina). All isolates harboured an 138,998-bp type 1 IncC plasmid that carried blaNDM-1, bleMBL, blaCMY-6, rmtC, aac(6')-Ib, and sul1 resistance genes. Additionally, the blaNDM-plasmids contained ISKpn8 an insertion sequence previously described as associated only to blaKPC. One isolate, a colistin-resistant E. coli, also carried a mcr-1-containing an IncI2 plasmid, which did not harbour additional resistance. The whole genome of K. quasipneumoniae subsp. quasipneumoniae isolate was fully sequenced. This isolate harboured, additionally to blaNDM, three plasmid-mediated quinolone resistance genes: qnrB4, qnrB52 and aac(6')-Ib-cr1. The E. cloacae isolate also harboured qnrA1. These findings alert to the underestimated horizontal dissemination of multidrug-resistant plasmids limiting treatment options with last resort antimicrobials.
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