ArticlePloS one2019
Characterization of melanin and optimal conditions for pigment production by an endophytic fungus, Spissiomyces endophytica SDBR-CMU319.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 117 citations in OpenAlex.
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- Bioactivity and textile dyeing potential of pigments produced by Arcopilus cupreus T8.Scientific reports · 2026Article
- Nutrient utilization and degradative enzyme activity of the dragon fruit canker pathogen,Microbiology (Reading, England) · 2026Article
- From Pigment Chemistry to Nanomaterials: Fungal Pigments as Reducing and Stabilizing Agents in Green Nanoparticle Synthesis.Microorganisms · 2026Review
- Extraction, Partial Characterization and Evaluation of the Biopotential of Melanin Pigment from an Indigenous non-conventional Fungus.Current microbiology · 2026Article
- Sustainable Production and Characterization of Eumelanin from Organically CultivatedInternational journal of molecular sciences · 2025Article
- A review on bacteria-derived antioxidant metabolites: their production, purification, characterization, potential applications, and limitations.Archives of pharmacal research · 2025Review
- The legacy of endophytes for the formation of bioactive agents, pigments, biofertilizers, nanoparticles and bioremediation of environment.World journal of microbiology & biotechnology · 2025Review
- Suppression of mycotoxins production and efficient chelation of heavy metals using natural melanin originated from Aspergillus flavus and Aspergillus carbonarius.BMC biotechnology · 2025Article
- Regulation of melanin production in fungi.Frontiers in fungal biology · 2025Review
- Biocompatible melanin from the marine black yeast Hortaea werneckii R23 with antioxidant and photoprotection property.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Fusarium verticillioides pigment: production, response surface optimization, gamma irradiation and encapsulation studies.BMC biotechnology · 2024Article
- Mechanisms and Virulence Factors ofJournal of fungi (Basel, Switzerland) · 2024Review
- Advances in Aureobasidium research: Paving the path to industrial utilization.Microbial biotechnology · 2024Review
- Production and characterization of melanin pigment from black fungus Curvularia soli AS21 ON076460 assisted gamma rays for promising medical uses.Microbial cell factories · 2024Article
- Bioproduction and optimization of newly characterized melanin pigment from Streptomyces djakartensis NSS-3 with its anticancer, antimicrobial, and radioprotective properties.Microbial cell factories · 2024Article
- The Metallotolerance and Biosorption of As(V) and Cr(VI) by Black Fungi.Journal of fungi (Basel, Switzerland) · 2024Article
- Characterization of melanin fromFrontiers in fungal biology · 2024Article
- Isolation, Identification, and Antibacterial Properties of Prodigiosin, a Bioactive Product Produced by a NewAntibiotics (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melanin is a natural pigment that is produced by filamentous fungi. In this study, the endophytic species, Spissiomyces endophytica (strain SDBR-CMU319), produced a brown-black pigment in the mycelia. Consequently, the pigment was extracted from the dried fungal biomass. This was followed by pigment purification, characterization and identification. Physical and chemical characteristics of the pigment showed acid precipitation, alkali solubilization, decolorization with oxidizing agents, and insolubility in most organic solvents and water. The pigment was confirmed as melanin based on ultraviolet-visible spectroscopy, Fourier-transform infrared, and electron paramagnetic resonance spectra analyses. The analyses of the elemental composition indicated that the pigment possessed a low percentage of nitrogen, and therefore, was not 3,4-dihydroxyphenylalanine melanin. Inhibition studies involving specific inhibitors, both tricyclazole and phthalide, and suggest that fungal melanin could be synthesized through the 1,8-dihydroxynaphthalene pathway. The optimum conditions for fungal pigment production from this species were investigated. The highest fungal pigment yield was observed in glucose yeast extract peptone medium at an initial pH value of 6.0 and at 25°C over three weeks of cultivation. This is the first report on the production and characterization of melanin obtained from the genus Spissiomyces.
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